Study of the Effects of Acute Exposure to Moderate Altitude Hypoxia on Prospective Memory.

ConditionsHypoxia Hypoxia Brain Hypoxia Altitude Simulation Test Hypoxia in Healthy Individuals Hypoxia, Altitude Hypoxia, Brain Altitude Altitude Hypoxia Normobaric Hypoxia

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-45

SponsorDirection Centrale du Service de Santé des Armées

About this trial

The goal of this study is to investigate whether prospective memory, i.e., memory for delayed intentions, is impaired at moderate altitude (4,000m).

It will also allow to study the effect of air and oxygen administration during hypoxia exposure.

The main questions it aims to answer are:

* Does moderate acute hypoxia impair prospective memory ? * If so, does air or oxygen adminsitration induce a restoration of prospective memory? Researchers will compare cognitive performance during normobaric hypoxia exposure to cognitive performance during normoxia (control situation).

Participants will:

* Session S0. Perform a battery of neuropsychological tests and questionnaires). EEG will be recorded during tests. A cheek swab will be performed. * Sessions S1 and S2. Perform several cognitive tasks while exposed to hypoxia and to normoxia (2 different sessions, randomized order) in a normobaric chamber. These are standardized cognitive tests administered on a computer and cognitive tests embedded in a flight simulator scenario. Various questionnaires will be performed on a regular basis. Several physiological measurements will be performed continuously: EEG, ECG, SpO2 and breathing rate. Blood pressure will be measured at the beginning and at the end of hypoxia/normoxia exposure. A blood sample will also be performed. At last, participants will inhale air or oxygen through a mask while making a cognitive task in the chamber.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Healthy volunteer

Has provided informed consent

Disqualifiers

Individuals who do not understand French

Pregnant or breastfeeding women

Cardiovascular risk factor

Infectious disease within the last 4 weeks

Trial design

Design model

Crossover

Treatments tested in this trial

Hypoxia exposure
Other intervention
Normobaric hypoxia exposure (FiO2 = 12,6%, equivalent to 4,000m) during 4h
Oxygen administration
Drug
Oxygen administration (FiO2 = 100%) through a mask during 10 minutes
Air administration
Other intervention
Air administration (Fi02 = 21%) through a mask during 10 minutes
Standardized cognitive tests (on a computer)
Behavioral
Auditory oddball, visual oddball, event-based prospective memory, time-based prospective memory, n-back.
Physiological measurements
Device
EEG, ECG, SpO2, breathing rate, eyetracking, blood pressure
Blood sample
Biological/Vaccine
A blood sample is collected for mitochondrial breathing analyses
Cognitive tests embedded in a flight simulator scenario
Behavioral
Event-based prospective memory and time-based prospective memory. Prepar3D flight simulator.

Treatment groups

50 Participants

are divided into 4 treatment groups

Group A: Normoxia-Air + Hypoxia-AirExperimental treatment 6 interventions

Group B: Hypoxia-Air + Normoxia-AirExperimental treatment 6 interventions

Group C: Normoxia-O2 + Hypoxia-O2Experimental treatment 6 interventions

Group D: Hypoxia-O2 + Normoxia-O2Experimental treatment 6 interventions

Trial outcomes

Primary outcomes

Change in event-based prospective memory accuracy between hypoxia and normoxia conditions

Accuracy (%) = Prospective memory target detection rate (number of targets correctly responded to / total number of targets presented × 100)

Time frame

Through study completion, an average of 1 month

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Direction Centrale du Service de Santé des Armées

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: