Study of the Relationship Between Curarization and Pneumoperitoneum in Laparoscopic Surgery
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorPoitiers University Hospital
About this trial
The number of surgical procedures is increasing worldwide (1). Laparoscopic surgery is one of the surgical techniques that has become indispensable. Laparoscopic surgery is less invasive than laparotomy. Laparoscopic surgery is performed in several stages, one of which involves the creation of a peritoneal detachment. This detachment is achieved by the addition of a gas (CO2), which requires total relaxation of the abdominal muscle fibers. To achieve this, it is advisable to administer a muscle relaxant called curare (2). Curare-induced neuromuscular block, its depth and its release must be monitored during surgery. Curares act as acetylcholine antagonists, inducing neuromuscular block by competing with this neurotransmitter. In France, only one type of device, called an accelerometer, is used to monitor curarization. This device couples electrical stimulation of a nerve with an accelerometer. Curarization can be said to be deep, moderate, residual or absent. Despite curarization appearing deep to the accelerometer, operating conditions do not always seem ideal for abdominal contraction. Indeed, the muscles tested with this device do not concern the muscles involved in laparoscopic surgery.
A currently unexploited surgical parameter, variation in insufflation pressure, could change our approach to intraoperative curarization.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
None
Trial population
Non-inclusion criteria: patients whose anesthetic maintenance is performed with Propofol IACP, patients who have undergone more than 3 intra-abdominal surgical procedures, patients with conversion to laparotomy.
Trial design
Design model
Other
Time perspective
Prospective
Treatments tested in this trial
No Intervention: Observational Cohort
Other interventionThis is a non-interventional observational study. It will simply look at the data and compare them between the monitors provided.
Treatment groups
200 Participants
are divided into 1 treatment groupGroup A: the group will be composed of patients undergoing laparoscopic surgery1 intervention
Trial outcomes
Primary outcomes
1
Primary outcome measure
Evaluate the relationship between variation in intra-abdominal pressure and depth of curarization.
Time frame
one daySecondary outcomes
1
secondary outcome
Study whether there is a link between variation in abdominal pressure level and postoperative pain.
Time frame
3 month2
secondary outcome
To study whether taking insufflation pressure into account reduces the need for intraoperative curare administration.
Time frame
one day3
secondary outcome
To study whether taking into account variations in insufflation pressure can reduce the dose of curare administered.
Time frame
one dayLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: