Gene therapy is a promising strategy to treat hearing loss and vestibular disorders, and Associated adenovirus (AAV) is shown as a good viral vector for inner ear therapy in animal models.
This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.
Patient ≥ 18 years old
Operative indication for a non-conservative resection of vestibular schwannoma, decided by the surgeon in accordance with the patient
Informed consent obtained
Patients with a french social protection (AME excluded)
Intravestibular or intra-cochlear extension of the tumor
Pregnant woman
Patient with administrative control
Medical contra-indication
Patients undergoing surgical resection of vestibular schwannoma.
Other
Prospective
Peroperative collect of inner ear cells
Other interventionAfter obtaining an informed consent during the preoperative medical visit, and if a non-conservative approach (translabyrinthine or transotic) is decided, the collect of inner ear cells will be performed during surgical approach. The sample will be collect in a sterile tube, and carried to the laboratory were it will be placed bon cell culture.
AAV transduction in inner ear cells
The transduction will be measured with immunostaining techniques
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Institut Pasteur
Lead sponsor
Assistance Publique - Hôpitaux de Paris
Collaborator
