Study on Pancreatic Islets in Patients Undergoing (Partial) Pancreatectomy (PRECISE)
ConditionDiabetes Mellitus
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorGerman Diabetes Center
About this trial
The study investigates the mechanisms underlying the pathogenesis of diabetes by examining structural and functional properties of islets of Langerhans in pancreas specimen from patients undergoing (partial) pancreatectomy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
None
Trial population
patients with or without diabetes who undergo (partial) pancreatectomy
Trial design
Design model
Case-control
Time perspective
Cross-sectional
Treatments tested in this trial
No intervention
Other interventionThe participants did not receive any study-specific intervention
Treatment groups
400 Participants
are divided into 3 treatment groupsGroup A: Type 2 diabetes1 intervention
Group B: Type 3 diabetes1 intervention
Group C: Non-diabetic controls1 intervention
Trial outcomes
Primary outcomes
1
Glycated hemoglobin
Proportion of glycated HbA1c (in %) as determined from pre-operative serum samples
Time frame
1 yearSecondary outcomes
1
Islet area
Size of pancreatic islets of Langerhans (in square micrometers) as determined by microscopic/morphometric analyses of appropriately stained thin sections of pancreatic tissue samples
Time frame
1 yearSponsors and contacts
Click on the lead sponsor to view all of their trials.
German Diabetes Center
Lead sponsor
Lukas Hospital, Neuss, Germany
Collaborator
Heinrich-Heine University, Duesseldorf
Collaborator
Florence Nightingale Hospital, Düsseldorf, Germany
Collaborator
Source ClinicalTrials.gov