Study on the Association Between Serrated Polyps and Metachronous Advanced Colorectal Neoplastic Lesions
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorChanghai Hospital
About this trial
This study aims to explore the risk factors associated with the development of ACN and same-site ACN in patients with SP, thereby informing the optimization of clinical surveillance strategies
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patients aged > 18 years;At least one SP detected during the index colonoscopy and pathologically confirmed as TSA or SSL (according to the 2019 WHO classification criteria);Underwent complete polypectomy during the index colonoscopy;Received regular follow-up at Changhai Hospital, with an interval of ≥ 6 months between the index and follow-up colonoscopies;Complete clinical and pathological data.
Disqualifiers
Incomplete colonoscopy or failed cecal intubation;Inadequate bowel preparation, defined as a Boston Bowel Preparation Scale (BBPS) score < 6 or a score < 2 in any bowel segment;Withdrawal time < 6 minutes;Diagnosis of hereditary cancer syndromes, such as familial adenomatous polyposis (FAP) or Lynch syndrome;Concurrent inflammatory bowel disease (IBD) or indeterminate colitis;History of colorectal cancer or other malignancies;Incomplete clinical or pathological records.
Trial population
Patients who underwent at least two surveillance colonoscopies at the Digestive Endoscopy Center of Shanghai Changhai Hospital between 2000 and 2025 were enrolled as study participants
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
750 Participants
are grouped into 2 trial groupsGroup A: Patients with serrated polyps at index colonoscopy and ACN at surveillance
Group B: Patients with serrated polyps at index colonoscopy and no ACN at surveillance
Trial outcomes
Primary outcomes
1
The occurrence of metachronous ACN
Time frame
At least 6 months after index colonoscopyLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: