Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-90
SponsorXijing Hospital
About this trial
Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs. At present, there is no unified diagnostic criteria for acute liver injury associated with heat stroke, and the commonly used prognosis scores are rarely included in liver injury indicators, which is not good for practicality.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
The patient voluntarily signs an informed consent form;
Adult patients who meet the criteria for heat stroke;
Heat stroke is defined as heat stroke (Heat Stroke, HS) is a serious fatal disease caused by heat injury factors acting on the body, accompanied by multiple organ damage.
Disqualifiers
Age <18 years old or >90 years old;
Patients with advanced tumors, Pregnancy or lactation;
Patients who missed out during treatment and whose data are incomplete.
Trial population
1. Healthy Volunteers with routine physical examination; 2. Heat stroke is defined as heat stroke (Heat Stroke, HS) is a serious fatal disease caused by heat injury factors acting on the body, accompanied by multiple organ(liver,kindey, lung ect) dysfunction.
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
Peripheral blood test
Diagnostic testCollect peripheral blood to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to find indicators related to disease deterioration and prognosis
Treatment groups
150 Participants
are divided into 3 treatment groupsGroup A: Control group1 intervention
Group B: Patients within the acute phase of disease1 intervention
Group C: Recovery stage of disease1 intervention
Trial outcomes
Primary outcomes
1
Prognosis
Rate of Surviving or Died Participants with Heat Stroke
Time frame
Day 30 and Day 90Secondary outcomes
1
Heat Stroke-associated kindey injury
Concentration of Creatinine(Cr)\>2 mg/dl or Urine output \< 500ml/Day
Time frame
Day 0, Day 7 and On the day of discharge after improvement2
Heat Stroke-associated liver injury
Concentration of ALT or AST \>80 U/L, Concentration of TBIL\>2mg/dl（34μmol/l）
Time frame
Day 0, Day 7 and On the day of discharge after improvementSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: