Study on the No.253 Lymph Node Metastasis Patterns in Left-Sided Colon and Rectal Cancer

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorCancer Institute and Hospital, Chinese Academy of Medical Sciences

About this trial

The goal of this observational study is to learn about the the pattern of metastasis of the No.253 lymph node in colorectal cancer. The main questions it aims to answer are: 1. What are the risk factors for metastasis to the No.253 lymph node? 2.What is the prognosis for patients with metastasis to the No.253 lymph node? Patients with descending colon cancer, sigmoid colon cancer, and rectal cancer who undergo curative surgery with dissection of the No.253 lymph node are included in this study

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age: 18-75 years;

Underwent laparoscopic left hemicolectomy, sigmoid colectomy, or rectal cancer radical surgery.

Postoperative pathology confirmed as adenocarcinoma.

No evidence of distant metastasis.

Disqualifiers

Previous history of malignant colorectal tumors.

Patients who have undergone multiple abdominal-pelvic surgeries.

Patients undergoing emergency surgery due to complications such as intestinal obstruction, intestinal perforation, or intestinal bleeding.

Surgery did not achieve R0 resection.

Trial population

Patients with left-sided colorectal cancer (left colon cancer, sigmoid cancer, rectal cancer) underwent laparoscopic surgery with dissection of No.253 lymph node.

Trial design

Design model

Cohort

Time perspective

Retrospective

Treatments tested in this trial

  • Laparoscopic colorectal surgery

    Procedure/Surgery

    Patients underwent laparoscopic left colectomy, sigmoid resection or rectal surgery according to the location of tumor.

Treatment groups

3,000 Participants
are divided into 1 treatment group
Group A: Cohort of left-sided colorectal cancer1 intervention

Trial outcomes

Primary outcomes

1

Metastatic rate of No.253 lymph node

Pathologically confirmed tumor cell infiltration in the No.253 lymph node

Time frame
About 10 days after surgery

Secondary outcomes

1

Number of harvested lymph nodes

Total number of lymph nodes dissected in the pathology report

Time frame
About 10 days after surgery
2

Incidence of postoperative complications

The proportion of short-term complications occurring within 30 days post-surgery

Time frame
30 days after surgery
3

5-year local recurrence rate

Local recurrence refers to the return of cancer in the same area where it originally developed, typically after treatment has been completed.

Time frame
5 years after surgery
4

5-year disease free survival rate

Disease free survival refers to the length of time after primary treatment during which a patient survives without any signs or symptoms of the cancer.

Time frame
5 years after surgery

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Lead sponsor

Peking Union Medical College Hospital

Collaborator

Peking University Cancer Hospital & Institute

Collaborator

China-Japan Friendship Hospital

Collaborator

Chinese PLA General Hospital

Collaborator