The study participants are patients with uterine fibroids and healthy physical examination subjects from the First Affiliated Hospital of Shandong First Medical University (Shandong Qianfoshan Hospital). The main purpose of this study is to analyze the correlation between uterine fibroids and vaginal microecology and cervical local immune function in patients of childbearing age.
Age 20-49 years old
Premenopausal
Clinical diagnosis of uterine myoma
Cervical liquid-based cytology and human papillomavirus typing test are negative
Used antibiotics, hormones, immunosuppressants and regulators within 1 month
Sex, vaginal irrigation or applied medicine 3 days before the vaginal discharge sampling
Pregnant, lactating or menstruating women
Uterus and uterine adnexa have other lesions
The First Affiliated Hospital of Shandong First Medical University (Shandong Qianfoshan Hospital) examined the uterine fibroid patients and healthy physical examination subjects.
Case-control
Cross-sectional
Microscopic examination of vaginal discharge
Diagnostic testUsing gram-stained smears to detect vaginal secretions, and then the concentration and diversity of bacterial flora are observed using a microscope.
Bacterial vaginitis (BV) of vaginal microecosystem-150 people in each group
Nugent score is currently an internationally accepted diagnostic method for BV. Lactobacillus, Gardnerella vaginalis, bacterioid bacteria and campylobacter with variable staining are evaluated by Gram staining and semi-quantitative evaluation method. The total score is the sum of the scores of the above 4 bacteria. 0 to 3 points: normal; 4 \~ 6 points: intermediate BV; ≥7 points: BV
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Lin Yuan
Lead sponsor
Qianfoshan Hospital
Sponsor institution
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