This clinical trial studies the use of both (co-use) oral nicotine pouches (ONPs) and alcohol among young adults and whether ONP nicotine concentration and flavor affect alcohol use. The co-use of nicotine and alcohol has grown among young adults and the increase in ONP use among young adults may be a contributing factor. ONPs do not contain tobacco leaf and may reduce cancer risk for those who switch from traditional tobacco products (e.g., cigarettes, moist snuff) to ONPs. However, given that alcohol is a cancer-causing agent, using ONPs might increase alcohol use among young adults, which may cause an increase in their risk of cancer. ONPs come in different nicotine concentrations and flavors, with young adults expressing a preference in nicotine concentration or flavor for use while drinking. The different nicotine concentrations and flavors could lead users to drink more or longer. Studying the co-use of ONPs and alcohol among young adults may help researchers understand whether ONP nicotine concentrations and flavors affect alcohol use. This information may be used to help guide future ONP regulations and cancer prevention interventions targeted to young adults.
21-30 years old
Use ONPs daily
Drink alcohol at least three days/week
Read and speak English
Use of other tobacco products > 10 days/month
Unstable or significant medical condition
Unstable or significant psychiatric conditions (past and stable conditions will be allowed)
History of cardiac event or distress within the past three months
Single group
Ecological Momentary Assessment
Other interventionComplete EMAs
Monitoring
Other interventionWear alcohol monitoring wristband
Nicotine Oral Pouch
DrugReceive ONPs
Survey Administration
Other interventionAncillary studies
Alcohol consumption
Alcohol consumption will be estimated with transdermal alcohol content (TAC) collected with a wristband worn by the participants.
Alcohol and ONP co-use side effects
The incidence of side effects including nausea, dizziness, and "head buzz" will be evaluated with the EMA surveys administered on the days of alcohol and ONP co-use.
Alcohol and ONP co-use next-day side effects
The incidence of next-day side effects including nausea, fatigue, sleep disruptions, and shakiness will be evaluated with the EMA surveys administered on the morning after a day where alcohol and ONP were co-used.
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