SWE to Detect Enthesitis in PsA: Relationship With SIRT2 Expression and Disease Activity
ConditionShear Wave Elastography
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University
About this trial
1. To assess the diagnostic utility of shear-wave elastography (SWE), gray-scale (GS) ultrasound, and Power Doppler (PD) in detecting Patellar and Achilles tendinopathy in psoriatic patients with and without arthritis. 2. Investigate the relation between SWE, GS ultrasound, and PD finding and SIRT2 expression levels. 3. Evaluate the association of the imaging findings and SIRT2 levels with psoriatic arthritis disease activity score.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients diagnosed as PsO by a dermatologist according to PASI score.
Patients diagnosed as PsA by rheumatologist according to CASPAR classification criteria for psoriatic arthritis
Adult patients of both sexes with an average > 18 years
Disqualifiers
Patients with a history of metabolic disease affecting tendons.
Patients with history of surgery, injury or trauma of patellar and/or Achilles tendon.
Patients with other rheumatological diseases.
Patients below 18.
Trial population
57 participants: 19 Psoriatic arthritis patients, 19 Psoriasis-only patients and 19 healthy control.
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
Musculoskeletal Ultrasound Device
DeviceMusculoskeletal Ultrasound assessment by LOGIQ P10 from General Electric (GE) Healthcare, each patient will be evaluated by grey scale, power doppler MSUS and Shear Wave Elastography (SWE)
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Assessment and comparting the diagnostic utility of shear-wave elastography (SWE) , Gray-scale (GS) ultrasound. and Power Doppler (PD) in detecting tendinopathy in psoriatic patients with and without arthritis.
Musculoskeletal Ultrasound assessment by LOGIQ P10 from General Electric (GE) Healthcare, a division of General Electric Company
Time frame
At baseline (single study visit)Secondary outcomes
1
Investigate the correlation between SWE, GS ultrasound and PD finding and SIRT2 expression levels and evaluate the correlation of the imaging finding and SIRT2 levels with psoriatic arthritis disease activity score (PASDAS).
Time frame
At baseline (single study visit)Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: