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Symptom Distribution and Pain Sensitization in Carpal Tunnel Syndrome

ConditionsCarpal Tunnel SyndromeCentral SensitisationPain, Radiating
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorSultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

About this trial

This study aims to compare central sensitization parameters between carpal tunnel syndrome (CTS) patients with extra median symptom distribution and those with typical, median nerve-related symptoms. Extra median sensory spread, observed in some CTS patients beyond the anatomical boundaries of the median nerve, may reflect central sensitization mechanisms. Using the Central Sensitization Inventory and pressure pain threshold measurements, this study will assess whether extra median symptom patterns are associated with increased central sensitization.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Having been diagnosed with carpal tunnel syndrome based on clinical and electrodiagnostic findings

Being between 18 and 65 years of age

Being literate

Agreeing to participate in the study

Disqualifiers

Having a history of concomitant diabetes, systemic inflammatory disease, active infection, or malignancy

Being <18 and >65 years of age

Being illiterate

Refusing to participate in the study

Trial population

Patients with CTS

Trial design

Design model

Case-only

Time perspective

Cross-sectional

Treatments tested in this trial

  • Nerve ultrasound

    Diagnostic test

    Ultrasonographic evaluation of the median nerve at the carpal tunnel and adjacent levels

  • Nerve conduction studies

    Diagnostic test

    Upper extremity nerve conduction studies including median-ulnar sensory and motor responses

  • Pressure pain threshold

    Diagnostic test

    Pain pressure threshold is used to measure deep muscular tissue pain sensitivity.

Treatment groups

80 Participants
are divided into 1 treatment group
Group A: Patients3 interventions

Trial outcomes

Primary outcomes

1

Pressure pain threshold

Pain pressure threshold (PPT) is used to measure deep muscular tissue sensitivity. Algometer is used in the measurement and low values are interpreted in favor of increased sensitivity.

Time frame
3 months
2

Katz hand diagram

The Katz Hand Diagram is a self-reported symptom map used to support the diagnosis of Carpal Tunnel Syndrome (CTS). Patients are asked to mark areas on a standardized hand diagram where they experience pain, numbness, or tingling. This tool helps clinicians assess whether symptoms follow a median nerve distribution and is commonly used in both clinical and research settings due to its simplicity and diagnostic value.

Time frame
3 months

Secondary outcomes

1

Central sensitization inventory (CSI)

Clinical instrument used in the diagnosis of central sensitization. A CSI part-A score of 40 and above is significant in the diagnosis. The score range is between 0 and 100, and as the score increases, the severity of sensitization symptoms increases.

Time frame
3 months
2

Visual analog scale

The visual analog scale (VAS) is a validated subjective measure for pain, scored in the 0-10 range (0:no pain; 10: worst pain).

Time frame
3 months
3

hand grip strength

Grip strength is a measure of muscle strength or the maximum force/tension produced by one's forearm muscles and is measured with a hand dynamometer.

Time frame
3 months
4

Median nerve conduction studies-latency measurement

Latency values obtained in bilateral median motor and sensory nerve conduction studies.

Time frame
3 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

Lead sponsor

Source ClinicalTrials.gov
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