Syncytiotrophoblast-derived Extracellular Vesicles in Placenta Previa and Accreta Spectrum

ConditionsPlacenta Previa Placenta Accreta Spectrum

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexFemale

Age18+

SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS

About this trial

The main goal of this case-control study is to quantify the levels of circulating syncytiotrophoblast-derived extracellular vesicles (STBEVs) in maternal blood in a population of women with placenta previa and placenta accreta spectrum.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Pregnant women with diagnosis of placenta previa and accreta spectrum (cases)

Healthy pregnant women

> 18 years

Disqualifiers

< 18 years

Twin pregnancies

Chronic Infections

Cancers

Trial design

Design model

Single group

Treatments tested in this trial

Blood sample
Procedure/Surgery
Blood sample

Treatment groups

70 Participants

are divided into 1 treatment group

Group A: Women with diagnosis of PP and PASExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Concentration of circulating EVs from blood

Analysis of circulating syncytiotrophoblast-derived extracellular vesicles in the third trimester of pregnancy of women with abnormal placentation (placenta previa and placenta accreta spectrum)

Time frame

9 months (three trimester of pregnancy)

Proteomics analysis of circulating EVs

Multi-omics profiling of circulating EVs cargo isolated from blood of pregnant women with abnormal placentation compared to healthy pregnant women

Time frame

9 months (three trimester of pregnancy)

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Lead sponsor

Source ClinicalTrials.gov

Apply now