Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-50
SponsorRush University Medical Center
About this trial
The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 18 - 50
English-speaking
Clinical evidence of ACL rupture with swelling
Participant must be undergoing ACL reconstruction surgery
Disqualifiers
Age <18 or >50
Presentation >3 weeks after initial injury
Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery
> Kellgren-Lawrence grade 2 changes on preoperative x-ray
Trial design
Design model
Parallel
Treatments tested in this trial
Synovial Fluid withdrawal at the preoperative clinic visit
Procedure/SurgerySynovial Fluid withdrawal at the preoperative clinic visit
Platelet-Rich Plasma (PRP) preparation and injection
Procedure/SurgeryPlatelet-Rich Plasma (PRP) preparation and injection
Synovial fluid withdrawal at the time of surgery
Procedure/SurgerySynovial fluid withdrawal at the time of surgery
3mL synovial fluid withdrawn at the preoperative visit
Procedure/Surgery3mL synovial fluid withdrawn at the preoperative visit
Treatment groups
99 Participants
are divided into 3 treatment groupsGroup A: Two Synovial Fluid WithdrawalsActive comparator 2 interventions
Group B: Platelet-Rich Plasma (PRP) and Two Synovial Fluid WithdrawalsExperimental treatment 3 interventions
Group C: 3mL Synovial Fluid Withdrawal and Synovial Fluid Withdrawal at the Time of SurgeryOther 2 interventions
Trial outcomes
Primary outcomes
1
Concentration of Collagen Type II Cytokine
Breakdown cytokine found in damaged cartilage
Time frame
Enrollment up to surgerySponsors and contacts
Click on the lead sponsor to view all of their trials.
Rush University Medical Center
Lead sponsor
Arthroscopy Association of North America
Collaborator
Source ClinicalTrials.gov
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