About this trial
The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident. Indeed, the low-income residents in several European countries, including Greece, had limited access to the healthcare system for several reasons. In addition, vulnerable populations, with patients suffering from opioid use disorders and incarcerated individuals being among them, do not have the same chances regarding health services, compared to the general population. According to the World Health Organization, physical activity is a key non-pharmaceutical intervention for both prevention of chronic non-communicable diseases and address of social health inequalities. Thus, this study will focus on specific population groups of the Region of Thessaly, Greece, who have limited access to healthcare services. It aims, primarily, to the assessment of demographic characteristics (i.e., body mass index, alcohol consumption, smoking, educational level etc), which are fundamental parameters for the assessment of health inequalities. Secondly, quality of life, physical activity levels and biomarkers in the level of Biochemistry (i.e., blood oxidative stress and inflammation) and Physiology (i.e., cardiorespiratory fitness, body composition) will be collected a well. All data will be integrated into an interactive digital platform that will be accessible by any putative stakeholder in the area of health system or administration. Based on scientifically robust data and evidence-based findings, the research team of the project will draft recommendations and guidelines that will be communicated to all stakeholders. To that end, the problem of limited access to health system that the examined populations face, will be highlighted and targeted actions and policies are expected to be adopted by local (i.e., in the province of Thessaly) and national (i.e., Greek) authorities. In this respect, non-pharmaceutical interventions and guidelines will be proposed towards the trajectory of holistically approaching the issue of health inequalities.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults (>18 years of age)
All healthy individuals who reside in rural and urban areas
All patients with non-communicable diseases who reside in rural and urban areas
Patients with opioid use disorders under medication for addiction treatment with methadone and buprenorphine
Disqualifiers
Minors (<18 years of age)
Individuals with communicable diseases
Trial population
Sources of study populations: Hospitals; Other health centers and structures in cities, towns or villages; National Organization for the Prevention and Treatment of Addictions (EOPAE); Correctional facilities (prisons)
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
6
Trial groupsSee each trial group below.
Trial outcomes
Primary outcomes
Demographic data
Body mass index, smoking, alcohol consumption, place of residence, health insurance, educational status, family status and financial status will be collected among others through a questionnaire.
Secondary outcomes
Physical activity
It will be measured through the international physical activity questionnaire (IPAC)
Quality of life
It will be measured through the SF-36 questionnaire. This instrument has a physical component and a mental component. Each domain is scored from 0 to 100. Higher score = better health or better quality of life.
Heroin craving
It will be measured using the heroin craving questionnaire (HCQ). The score is calculated with a 7-point Likert scale ranging from 1 (i.e., strongly disagree) to 7 (i.e., strongly agree). Higher values = higher craving for heroin use. It applies only to the patients with opioid use disorders.
Concentration of reduced glutathione (GSH)
The concentration of GSH, a crucial antioxidant metabolite, will be measured in the blood of sub-population of the volunteers
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Thessaly
Lead sponsor
General Hospital of Trikala
Collaborator
General Hospital of Larissa
Collaborator
National Organization for the Prevention and Treatment of Addictions (EOPAE)
Collaborator
5th Regional Health Authority of Thessaly & Sterea
Collaborator
Correctional Facility (Prison) of Trikala
Collaborator
Region of Thessaly
Collaborator
University of Thessaly, Department of Nutrition and Dietetics
Collaborator