Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Thessaly

About this trial

The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident. Indeed, the low-income residents in several European countries, including Greece, had limited access to the healthcare system for several reasons. In addition, vulnerable populations, with patients suffering from opioid use disorders and incarcerated individuals being among them, do not have the same chances regarding health services, compared to the general population. According to the World Health Organization, physical activity is a key non-pharmaceutical intervention for both prevention of chronic non-communicable diseases and address of social health inequalities. Thus, this study will focus on specific population groups of the Region of Thessaly, Greece, who have limited access to healthcare services. It aims, primarily, to the assessment of demographic characteristics (i.e., body mass index, alcohol consumption, smoking, educational level etc), which are fundamental parameters for the assessment of health inequalities. Secondly, quality of life, physical activity levels and biomarkers in the level of Biochemistry (i.e., blood oxidative stress and inflammation) and Physiology (i.e., cardiorespiratory fitness, body composition) will be collected a well. All data will be integrated into an interactive digital platform that will be accessible by any putative stakeholder in the area of health system or administration. Based on scientifically robust data and evidence-based findings, the research team of the project will draft recommendations and guidelines that will be communicated to all stakeholders. To that end, the problem of limited access to health system that the examined populations face, will be highlighted and targeted actions and policies are expected to be adopted by local (i.e., in the province of Thessaly) and national (i.e., Greek) authorities. In this respect, non-pharmaceutical interventions and guidelines will be proposed towards the trajectory of holistically approaching the issue of health inequalities.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adults (>18 years of age)

All healthy individuals who reside in rural and urban areas

All patients with non-communicable diseases who reside in rural and urban areas

Patients with opioid use disorders under medication for addiction treatment with methadone and buprenorphine

Disqualifiers

Minors (<18 years of age)

Individuals with communicable diseases

Trial population

Sources of study populations: Hospitals; Other health centers and structures in cities, towns or villages; National Organization for the Prevention and Treatment of Addictions (EOPAE); Correctional facilities (prisons)

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

2,000 Participants
are grouped into 6 trial groups

6

Trial groups

See each trial group below.

Group A: Patients with non-communicable diseases - residents of rural areas
Group B: Patients with non-communicable diseases - residents of urban areas
Group C: Healthy volunteers - residents of rural areas
Group D: Healthy volunteers - residents of urban areas
Group E: Patients with opioid use disorders under medication for addiction treatment
Group F: Individuals incarcerated in correctional facilities (prisons)

Trial outcomes

Primary outcomes

1

Demographic data

Body mass index, smoking, alcohol consumption, place of residence, health insurance, educational status, family status and financial status will be collected among others through a questionnaire.

Time frame
Data will be collected at Baseline

Secondary outcomes

1

Physical activity

It will be measured through the international physical activity questionnaire (IPAC)

Time frame
Data will be collected at Baseline
2

Quality of life

It will be measured through the SF-36 questionnaire. This instrument has a physical component and a mental component. Each domain is scored from 0 to 100. Higher score = better health or better quality of life.

Time frame
Data will be collected at Baseline
3

Heroin craving

It will be measured using the heroin craving questionnaire (HCQ). The score is calculated with a 7-point Likert scale ranging from 1 (i.e., strongly disagree) to 7 (i.e., strongly agree). Higher values = higher craving for heroin use. It applies only to the patients with opioid use disorders.

Time frame
Data will be collected at Baseline
4

Concentration of reduced glutathione (GSH)

The concentration of GSH, a crucial antioxidant metabolite, will be measured in the blood of sub-population of the volunteers

Time frame
Data will be collected at Baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Thessaly

Lead sponsor

General Hospital of Trikala

Collaborator

General Hospital of Larissa

Collaborator

National Organization for the Prevention and Treatment of Addictions (EOPAE)

Collaborator

5th Regional Health Authority of Thessaly & Sterea

Collaborator

Correctional Facility (Prison) of Trikala

Collaborator

Region of Thessaly

Collaborator

University of Thessaly, Department of Nutrition and Dietetics

Collaborator