Systemic Inflammation, Thyroid Autoimmunity and Neuroretinal Changes in Graves Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorElazıg Fethi Sekin Sehir Hastanesi
About this trial
This retrospective observational study aims to evaluate the relationship between systemic inflammatory parameters, thyroid autoimmunity markers, and neuroretinal structures in patients with Graves disease. Medical records of patients diagnosed with Graves disease and healthy control subjects evaluated at Elazığ Fethi Sekin City Hospital between August 2018 and January 2026 will be reviewed. Optical coherence tomography (OCT) measurements, including macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness, will be analyzed. Laboratory parameters such as complete blood count-derived inflammatory indices, C-reactive protein, thyroid function tests, and thyroid autoantibodies will also be recorded. The study will compare neuroretinal parameters between healthy controls, Graves disease patients without ophthalmopathy, and Graves disease patients with ophthalmopathy, and will investigate potential associations between systemic inflammation, thyroid autoimmunity, and neuroretinal structural changes.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age ≥ 18 years
Disqualifiers
Presence of glaucoma, optic neuropathy, or retinal vascular diseases
Trial population
The study population will consist of adult patients diagnosed with Graves' disease who are followed in the endocrinology and ophthalmology clinics of the participating institution. Patients who meet the inclusion criteria and have available optical coherence tomography (OCT) measurements and laboratory data will be included in the patient group. The control group will consist of age- and sex-matched healthy volunteers without a history of thyroid disease or ocular pathology, recruited from individuals undergoing routine ophthalmologic examination. All participants will be evaluated for neuroretinal structural parameters using OCT and systemic inflammatory markers obtained from laboratory tests.
Trial design
Design model
Case-control
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
100 Participants
are grouped into 3 trial groupsGroup A: Healthy Controls
Group B: Graves Disease Without Ophthalmopathy
Group C: Graves Disease With Ophthalmopathy
Trial outcomes
Primary outcomes
1
Peripapillary Retinal Nerve Fiber Layer Thickness
Evaluation and comparison of peripapillary retinal nerve fiber layer thickness values in different quadrants among study groups.
Time frame
Retrospective evaluation of OCT measurements obtained between August 2018 and January 20262
Macular Thickness Measured by Optical Coherence Tomography
Comparison of macular thickness measurements among healthy controls, Graves disease patients without ophthalmopathy, and Graves disease patients with ophthalmopathy.
Time frame
Retrospective evaluation of OCT measurements obtained between August 2018 and January 2026Sponsors and contacts
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Source ClinicalTrials.gov