The aim of the SAID study is to create a national resource in Sweden to enable comprehensive immunological analyses of an extremely complex and clinically challenging group of individuals with variable forms of immune system dysregulation. We hope to establish a biobank of primarily blood and fecal samples from children and adults, with confirmed or suspected immune dysregulation, as well as age- and sex- matched healthy controls, for comparisons of immune cell/mediator alongside various clinical presentations of these immunological diseases as well as microbiome samples as possible a possible modifier of clinical presentations. The project will also include the establishment of a national database with deep immunological data, treatment and clinical outcomes for these patients, accessible to participating researchers and clinicians.
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All subjects, children and adults in Sweden and referred to Swedish centers with known or suspected immune dysregulation.
Cohort
Prospective
Immunomodulation
Combination productVariable protocols for combined immunomodulatory therapies currently in use for different forms of immune dysregulation
control of immune dysregulation
Remission and control of immune dysregulation manifested as reduced inflammation, symptom relieve and halted immunoproliferation for examples
Exploratory immunological parameters
Systems-level immunomonitoring for exploration of cell state changes in response to therapy
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Karolinska Institutet
Lead sponsor
Karolinska University Hospital
Collaborator
Skane University Hospital
Collaborator
Sahlgrenska University Hospital
Collaborator
Uppsala University Hospital
Collaborator
Region Halland
Collaborator
Region Jönköping County
Collaborator
