Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire de Nice
About this trial
The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Invasive mechanical ventilation for more than 48 hours
SpO2> 90% with FiO2 ≤40% and PEEP ≤5 cmH2O
Cough effectiveness on tracheal aspirations
Lack of hemodynamic instability and of disorders of consciousness
Disqualifiers
Age <18 years and pregnant women
Patients with a decision of not to resuscitate
Poor echogenicity
Severe mitral valve disease (leakage and/or stenosis, bioprosthesis)
Trial design
Design model
Single group
Treatments tested in this trial
Spontaneous breathing trial
Procedure/SurgeryTo perform cardiac and lung echography before and during a spontaneous breathing trial
Treatment groups
250 Participants
are divided into 1 treatment groupGroup A: high-risk of weaning-induced pulmonary edemaOther 1 intervention
Trial outcomes
Primary outcomes
1
Proportion of patients experiencing left and/or right ventricular
Left ventricular systolic function will be assessed by several
Time frame
24 monthsSecondary outcomes
1
Proportion of patients experiencing a weaning-induced pulmonary
WiPO is defined by new acute respiratory failure during spontaneous
Time frame
24 months2
Clinical and echocardiographic predictors of weaning-induced
To test the ability of different clinical and echocardiographic
Time frame
24 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov