TA-65 and Aging Associated Microvascular Dysfunction
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorMedical College of Wisconsin
About this trial
The goal of this clinical trial is to test whether activation of telomerase with a dietary supplement (TA-65) improves microvascular function.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy Adults 18 - 35 and 65+ years of age
Subjects with clinical diagnosis of CAD
Disqualifiers
36-64 years of age without clinical diagnosis of CAD
Self-reported habitual vigorous exercise (>20 min, 3 times per week, 1 yr)
Major Adverse Cardiovascular Event (MACE) in the last year (heart attack, stroke)
Heart Failure
Trial design
Design model
Crossover
Treatments tested in this trial
TA-65
Dietary supplementTA-65 is a purified small molecule extracted from Astragalus root
Placebo
Other interventionInactive formulation
Treatment groups
180 Participants
are divided into 2 treatment groupsGroup A: TA-65Experimental treatment 1 intervention
Group B: PlaceboPlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Nitric Oxide Mediated Endothelium-Dependent Vasodilation via Laser Doppler Flowmetry Coupled with Intradermal Microdialysis
Cutaneous microvascular function measured via laser Doppler flowmetry coupled with intradermal microdialysis of non-specific nitric oxide synthase inhibitor, L-NAME
Time frame
28 daysSecondary outcomes
1
Systemic Blood Pressure
Brachial systolic, and diastolic blood pressure will be measured via standard brachial blood pressure cuff
Time frame
28 daysLocations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Medical College of Wisconsin
Lead sponsor
University of Louisville
Collaborator
Penn State University
Collaborator
Source ClinicalTrials.gov
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