This study aims to establish the first county-level, population-based prospective cohort in Taining County, Fujian Province, China. The cohort will include at least 20,000 residents aged 18 years or older. The project will systematically collect questionnaires, physical measurements, laboratory tests, imaging data, and biological samples to build a multi-dimensional health database and biobank. Through 3-year follow-up, the study seeks to reveal the epidemiological patterns and risk factors of chronic diseases, characterize the natural course of multimorbidity and aging syndromes, and develop a comprehensive chronic disease management model suitable for rural and mountainous regions.
Age ≥18 years, male or female.
Resident of Taining County for ≥6 months and expected to remain in the county for at least the next 3 years.
Full civil capacity and able to understand study procedures.
Willing to voluntarily participate and provide written informed consent.
Refusal to sign informed consent.
Severe psychiatric disorders or cognitive impairment preventing participation.
End-stage disease with expected survival <1 year.
Long-term migrants (≥6 months per year outside the county), unable to guarantee follow-up.
The study population will consist of community-dwelling adult residents of Taining County, a mountainous region in Fujian Province, China. Eligible participants are men and women aged 18 years and older who have lived in the county for at least 6 months and are expected to remain for the next 3 years. A total of at least 20,000 participants will be enrolled at baseline through community-based recruitment and household registration systems. The population reflects the demographic and health characteristics of a rural county with a relatively high proportion of older adults and a growing burden of chronic diseases such as hypertension, diabetes, and cardiovascular disease.
Cohort
Prospective
Not listed
Incidence of Major Adverse Cardiovascular Events (MACE)
Composite outcome including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. Events will be ascertained through active follow-up and confirmed using medical records and hospital discharge summaries.
Incidence of Cardiovascular and Cerebrovascular Events
New onset of coronary heart disease, stroke, or heart failure, identified through follow-up visits and confirmed using medical records.
Heart Failure-Related Rehospitalization Rate
Rehospitalization due to worsening heart failure among participants diagnosed with heart failure, confirmed by hospital admission records.
Bleeding Events
Occurrence of clinically significant bleeding events, including gastrointestinal bleeding and other major or clinically relevant non-major bleeding, identified through follow-up and medical records.
Health Economics Outcomes
Direct medical costs, hospitalization expenses, outpatient visit costs, medication costs, and health service utilization related to chronic disease management, collected from medical records and insurance data.
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