Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50+
SponsorTan Tock Seng Hospital
About this trial
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems. This is due to a lack of normative data for older adults and reliable risk stratification methods to develop effective approaches to the prevention of frailty.
In this study, the investigators plan to form a common dataset for phenotype identification, risk stratification of frailty and its targeted treatment plans in the at-risk and mildly frail population.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥ 50y
Asian ethnicity
First diagnosis (stroke, Traumatic Brain Injury (TBI), knee osteoarthritis, breast cancer)
Living in community
Disqualifiers
Nursing home or dormitory resident
Non-resident status in Singapore (e.g. foreign worker, tourist, temporary visit pass)
Impairments affecting understanding of questionnaires and tasks: e.g. severe deafness, severe visual impairment and severe /global aphasia,
Presence of active fractures, dislocations, non-weight bearing status, burns, unhealed wounds, active skin infections/eczema and agitated behaviour or delirium
Trial population
Patients in both outpatient and inpatient clinics
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
500 Participants
are grouped into 4 trial groupsGroup A: Stroke
Group B: Traumatic Brain Injury
Group C: Breast Cancer
Group D: Knee Osteoarthritis
Trial outcomes
Primary outcomes
1
Incidence (rates) of Frailty
Based off different outcomes determined in the study
Time frame
Through study's data collection period, up to 4 years2
Severity of Frailty
Based on CFS - 9-point clinical assessment tool evaluating an individual's frailty status; maximum score: 9; higher score indicates increased frailty.
Time frame
For inpatient: Visit 1 (within 2 weeks of admission) to Visit 6 (end of 3rd year); For outpatient: Visit 1 (baseline) to Visit 4 (end of 3rd year)Secondary outcomes
1
Body Composition Analysis (BCA)
Measured using weak electrical current passed from feet to estimate proportion of muscle, fat and water mass.
Time frame
For inpatient: Visit 3 (6 months post-event) to Visit 6 (end of 3rd year); For outpatient: Visit 1 (baseline) to Visit 4 (end of 3rd year)2
Short Physical Performance Battery (SPPB)
Measures 3 components: (1) 5 times chair stand test; (2) Balance test; (3) Gait speed (4m walk test). Score from 0-12 with higher score indicating greater functional capacity.
Time frame
For inpatient: Visit 1 (within 2 weeks of admission) to Visit 6 (end of 3rd year); For outpatient: Visit 1 (baseline) to Visit 4 (end of 3rd year)3
Hand Grip Strength (kg)
Measured seated with arms on a table bent to 90° using a dynamometer (mean of 3 readings will be recorded)
Time frame
For inpatient: Visit 1 (within 2 weeks of admission) to Visit 6 (end of 3rd year); For outpatient: Visit 1 (baseline) to Visit 4 (end of 3rd year)4
Muscle Ultrasound imaging
Determines state of muscle health of arm, thigh and jaw muscles through size, area and structural properties.
Time frame
For Inpatient: Visit 1 (within 2 weeks of admission), Visit 2 (1 week pre-discharge)Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Tan Tock Seng Hospital
Lead sponsor
Rehabilitation Research Institute of Singapore (RRIS)
Collaborator
Woodlands Health (WH)
Collaborator
Source ClinicalTrials.gov