Muscle changes including myosteatosis are reported as highly prevalent in metabolic dysfunction-associated steatotic liver disease (MASLD). Recent studies highlighted a link between muscle fat content and liver disease severity. Conversely, MASLD histological remission though diet or metabolic surgeries is also linked to a decrease in muscle fat content. Therefore, skeletal muscle appears as a potential target to treat MASLD.
confirmed MASLD at abdominal imaging
confirmed excessive muscle lipid content at imaging
stable weight
severe comorbidities including active malignancies, neuromuscular degenerative diseases
contraindications to physical activity
excessive alcohol consumption
Parallel
High-intensity interval training
Other interventionHigh-intensity interval training
Moderate intensity exercise training
Other interventionModerate intensity exercise training
Low intensity exercise training
Other interventionLow intensity exercise training
the impact of physical activity on muscle and liver phenotypes
the investigators will assess at baseline and every four weeks till study completion the impact of intervention on liver phenotype assessed by transient elastography and muscle phenotype assessed by MRI
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Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Lead sponsor
Concerted Research Action
Collaborator
Fonds National de la Recherche Scientifique
Collaborator
