About this trial
This study aims to understand the neural, behavioral and clinical effects of temporal interference (TI), a type of neuromodulation method, in healthy populations and in individuals with anxiety and stress-related conditions.
Eligibility criteria
Qualifiers
Written informed consent.
Fluent English speaker.
Both sexes and all ethnic origins, between 18 and 65 years old.
Absence of current moderate to severe illicit drug use as assessed by subject history (AUDIT>=8 and/or DAST>2).
Disqualifiers
Pregnant or currently breast-feeding women or any woman of childbearing potential who is seeking to become pregnant or suspects that she may be pregnant, as assessed by subject report and/or urine pregnancy screen.
Contraindications to MRI scanning (including presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia, as assessed with the standard MRI screening form from the CABI, FERN or CSI.
Unable to fit comfortably in the scanner.
Contraindication to TI and/or TMS (including history of epilepsy, metallic implants in the head and/or neck, brain stimulators, vagus nerve stimulators, VP shunt, pacemakers)
Trial design
Treatments tested in this trial
- Electrical stimulation device
- Electrical stimulation device