Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexMale
Age18-50
SponsorThe University of Hong Kong
About this trial
Cancer treatment can affect the testicular function, including sperm and hormonal functions. The aim of this study is to assess the testicular function and semen quality in young men who recover from childhood and adolescent cancer in Hong Kong. This can provide more information for pre-treatment counselling as well as improve post treatment survivorship care. The testicular function will be compared to aged-matched controls from men attending the Family Planning Association for premarital check-up.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were < 18 years old.
> 18 years old to 50 years old
Cancer in remission for at least 2 years
Disqualifiers
Unable to ejaculate by masturbation to provide semen samples
Cryptorchidism, testicular cancer, history of vasectomy
On testosterone replacement therapy
Refusal to join the study
Trial population
Target participant Population * The target population for the trial will be men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were \< 18 years old. * Aged-matched controls from men attending the Family Planning Association for premarital check-up
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
Hormonal profile
Other interventionBlood for FSH, LH, testosterone
Semen analysis
Other interventionSemen analysis
Questionnaire
Other interventionThe European Male Ageing Study (EMAS) questionnaire
Treatment groups
200 Participants
are divided into 2 treatment groupsGroup A: Male childhood and adolescent cancer survivors3 interventions
Group B: Controls3 interventions
Trial outcomes
Primary outcomes
1
Sperm concentration
Sperm concentration
Time frame
up to 3 monthsSecondary outcomes
1
Semen parameters
Based on the WHO criteria
Time frame
up to 3 monthsOther outcomes
1
Testicular volume
Measured with the Prader orchidometer
Time frame
up to 3 months2
Hormonal profile
Serum level of testosterone
Time frame
up to 3 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
The University of Hong Kong
Lead sponsor
Queen Mary Hospital, Hong Kong
Collaborator
Prince of Wales Hospital, Shatin, Hong Kong
Collaborator
Hong Kong Children's Hospital
Collaborator
Source ClinicalTrials.gov