Testing a Registry-Based Strategy (ACT+) to Reduce Loss to Follow-Up in Rheumatic Heart Disease Screening in Uganda

ConditionRheumatic Heart Disease

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

AgeNot listed

SponsorChildren's Hospital Medical Center, Cincinnati

About this trial

This study aims to improve follow-up care after positive rheumatic heart disease (RHD) screening in Northern Uganda. It will identify barriers and co-develop an enhanced ACT+ strategy, then evaluate its effectiveness in increasing linkage to confirmatory echocardiography, along with its adoption, acceptability, and feasibility. Secondary outcomes include time to diagnosis, initiation of treatment, and factors influencing implementation.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

18 years of age or older

Received a positive ADUNU echocardiographic screening result within the past 24 months OR parent/legal guardian of a minor who received a positive ADUNU echocardiographic screening result within the past 24 months

Employed at an ADUNU-participating facility or confirmatory echo facilities at the time of study

Holds a designated ADUNU role (nurse screener, confirmatory provider, or referral support staff) or is involved in RHD screening, diagnosis or care

Disqualifiers

No formal exclusion criteria beyond inability to provide informed consent. Individuals with significant cognitive or communication impairment precluding interview participation will not be enrolled.

Trial design

Design model

Parallel

Treatments tested in this trial

The ACT+ Strategy
Other intervention
The Active Community Case Management Tool (ACT) is a cloud-based, dynamic RHD case management tool developed by CCHMC in partnership with global stakeholders, including UHI and the RRCU. ACT provides real-time data on patient status, clinical outcomes, and care processes, supporting both individual patient management (electronic medical record functions) and system-level quality improvement (registry and dashboard functions).

Treatment groups

16 Participants

are divided into 4 treatment groups

Group A: Inspiration/Discovery (1A)No intervention 0 interventions

Group B: Ideation/Design (1B)No intervention 0 interventions

Group C: Healthcare Facilities will receive ACT+ InterventionActive comparator 1 intervention

Group D: Control: Standard of CareNo intervention 0 interventions

Trial outcomes

Primary outcomes

Facility-level linkage to confirmation rate

The proportion of individuals with a positive ADUNU screening result who complete confirmatory echocardiography within the 9-month intervention period.

Time frame

9 months

Secondary outcomes

Time (days) from positive screen to confirmatory echocardiography

% providers entering \>90% of screening records OR completing all monthly outreach activities

Time frame

9 months

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Children's Hospital Medical Center, Cincinnati

Lead sponsor

Uganda Heart Institute

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: