Health TrialsbyHealthPanel

Testosterone-induced Muscle Memory and Underlying Mechanisms

ConditionSkeletal Muscle Physiology
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age18-40
SponsorMorten Hostrup, PhD

About this trial

The purpose of this project is to investigate underlying mechanisms of testosterone- and resistance training-induced muscle hypertrophy and muscle memory in humans.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Healthy men and women

BMI of <26 and normal ECG and blood pressure

Disqualifiers

Smoking

Chronic disease,

Use of prescription medication

Pain due to current or previous musculoskeletal injury

Trial design

Design model

Parallel

Treatments tested in this trial

  • Testosterone Undecanoate

    Drug

    Following testosterone/placebo injection, participants undergo supervised resistance training for 4 weeks. This period is followed by a washout period with no drug and either continued resistance training or detraining for 16 weeks. Thereafter, another 4-week period with supervised resistance training is commenced, with no drug.

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: TestosteroneExperimental treatment 1 intervention
Group B: PlaceboPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Fiber cross-sectional area

Immunohistochemistry to determine fiber cross-sectional area

Time frame
The change in fiber cross-sectional is assessed at baseline, 4, 20 and 24 weeks
2

Myonuclei

Immunohistochemistry to determine number of myonuclei

Time frame
The change in myonuclei is assessed at baseline, 4, 20 and 24 weeks
3

Skeletal muscle proteome

Pathway enrichment analysis of the muscle proteome using mass spectrometry-based proteomics

Time frame
The change in the muscle proteome is assessed at baseline, 4, 20 and 24 weeks

Secondary outcomes

1

Lean mass

Lean mass assessed by dual X-ray absorptiometry (DXA)

Time frame
The change in lean mass is assessed at baseline, 4, 20 and 24 weeks
2

Satellite cells

Immunohistochemistry to determine number of satellite cells

Time frame
The change in satellite cells is assessed at baseline, 4, 20 and 24 weeks
3

Muscle strength

1-repetition maximum

Time frame
The change in 1-repetition maximum is assessed at baseline, 4, 20 and 24 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Morten Hostrup, PhD

Lead sponsor

University of Copenhagen

Sponsor institution

Source ClinicalTrials.gov
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