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The ACCELERATE Pilot Trial

ConditionSurgery Complications
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60+
SponsorOttawa Hospital Research Institute

About this trial

The Advancing Cognition and Cognitive reserve before ELective surgery to Enhance cognitive Recovery And TrajEctories (ACCELERATE) Pilot Trial estimates whether our novel, coach-supported cognitive prehabilitation strategy will achieve adequate intervention adherence in the context of a feasible multicenter trial protocol.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age >/= 60 years

Planned, inpatient, surgical procedures: abdominal, orthopedic, spine, thoracic, pelvic, ENT, and vascular

Clinical Frailty Scale (CFS) score >/= 4

Expected time to surgery >/= 4 weeks

Disqualifiers

Cardiac and intracranial neurosurgery procedures

Visual impairment

Lack of English fluency

Trial design

Design model

Single group

Treatments tested in this trial

  • Cognitive Prehabilitation

    Behavioral

    home-based, online, adaptive, multidomain cognitive prehabilitation program, using a cognitive training platform (Lumosity \[Lumos Labs\]), enhanced by theory- and evidence-informed structured coaching.

Treatment groups

103 Participants
are divided into 1 treatment group
Group A: Intervention (cognitive prehabilitation)Experimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Intervention adherence

≥75% of intervention participants completing \>/=10 hrs of cognitive prehabilitation

Time frame
From baseline until surgery; intervention duration varies by participant and continues through the preoperative period (minimum of 4 weeks pre-surgery)

Secondary outcomes

1

Monthly recruitment

≥4 participants per center per month (a 40% recruitment rate; full trial would require 36 months to complete)

Time frame
1 month
2

Primary outcome ascertainment

≥ 90% of participants with ≥ 6 complete in-hospital delirium assessments

Time frame
Delirium will be assessed at the following timepoints after surgery: 1 hour after emergence, and twice daily on postop days 1, 2 and 3 at 08:00 and 20:00; 7 total

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ottawa Hospital Research Institute

Lead sponsor

Canadian Anesthesiologists' Society

Collaborator

University of Ottawa Anesthesiology and Pain Medicine

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: