The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma

ConditionAsthma

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age14-75

SponsorShanghai University of Traditional Chinese Medicine

About this trial

Asthma is one of the most common chronic respiratory diseases. Previous study found a series of differentially expressed genes and proteins (transgelin-2, metallothionein-2, ezrin) in asthmatic rat. The aim of the study is to investigate the changes and associations of these gene with asthma in human.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Males or females, aged 14-75 years;

Patients with a definite diagnosis of bronchial asthma;

The diagnosis of asthma according to the Global Initiative for Asthma (GINA), with positive bronchodilator responsiveness (reversibility) test;

Healthy volunteers without respiratory symptoms such as cough, wheezing, chest tightness or dyspnea;

Disqualifiers

Patients with chronic obstructive pulmonary disease or other airway disease;

Complicated with other severe primary diseases (including hypertension, cancer, hyperthyroidism, bronchiectasia, cardiac insufficiency) and conditions that would prevent participation in the trial or put the participant at risk;

Women who are known to be pregnant or breastfeeding;

Not willing to participate;

Trial population

Participants with asthma or non-asthma

Trial design

Design model

Case-control

Time perspective

Retrospective

Treatments tested in this trial

No intervention
Diagnostic test
No intervention

Treatment groups

100 Participants

are divided into 2 treatment groups

Group A: Asthma1 intervention

Group B: Control1 intervention

Trial outcomes

Primary outcomes

Difference in gene expression of transgelin-2, metallothionein-2 and ezrin between controls and asthmatic patients

PCR test of gene expression of transgelin-2, metallothionein-2 and ezrin between controls and asthmatic patients

Time frame

Two year

Association of transgelin-2, metallothionein-2 and ezrin with asthma

Correlation analysis between gene expressions of transgelin-2, metallothionein-2, ezrin and current asthmatic tests (pulmonary function, fractional exhaled nitric oxide,immunoglobulin E, serum eosinophil counts, interleukin-5, etc)

Time frame

Two year

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Shanghai University of Traditional Chinese Medicine

Lead sponsor

Xiangya Hospital of Central South University

Collaborator

National Natural Science Foundation of China

Collaborator

Source ClinicalTrials.gov

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