The Biological Rhythm of Human Metabolite
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-30
SponsorShandong Provincial Hospital
About this trial
The circadian regulation in mammals have been known for a long time. A special group of clock genes, organized in feedback loops, are responsible for the circadian regulation in both the SCN and peripheral organs. The central clock is mainly entrained by the light-dark cycle, while the peripheral ones in organs such as liver and intestine, are more influenced by the feeding-fasting cycles. The coordination of central and peripheral clocks is thought to be essential in the maintenance of physiological homeostasis.This study aim to investigate the association between biological rhythm and metabolism.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Male or female；
Aged of 18 to 30 years old;
Disqualifiers
Presence of pituitary/hypothalamic disorders, polycystic ovarian syndrome， thyroid disorders, hypertension, malignant tumor, cardiac insufficiency，hepatic or renal insufficiency, gastrointestinal disorders and acute infection;
Receiving psychotropic or hormonal medications including hormonal contraception and hormone therapies;
Taking lipid-lowering agents or hypoglycemic agents and other drugs that known to influence cardiovascular health;
Pregnancy or lactation women;
Trial population
Adults aged of 18 to 30 years old.
Trial design
Design model
Cohort
Time perspective
Other
Treatments tested in this trial
Not listed
Trial groups
200 Participants
are grouped into 4 trial groupsGroup A: male, non-obese
Group B: male, obese
Group C: female, non-obese
Group D: female, obese
Trial outcomes
Primary outcomes
1
circadian rhythms of serum lipid levels （the change of serum lipid levels within 24 hours）
Time frame
Measured at baseline, and every 10 years during the 40-year follow-up periodSecondary outcomes
1
circadian rhythms of gonadal hormone and gonadotropin（the change of gonadal hormone and gonadotropin within 24 hours）
Time frame
Measured at baseline, and every 10 years during the 40-year follow-up period2
circadian rhythms of serum total bile acids（the change of serum total bile acids within 24 hours）
Time frame
Measured at baseline, and every 10 years during the 40-year follow-up period3
change in urine metabolite
Time frame
Measured at baseline, and every 10 years during the 40-year follow-up period4
change in intestinal flora
Time frame
Measured at baseline, and every 10 years during the 40-year follow-up periodSponsors and contacts
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Source ClinicalTrials.gov