Health TrialsbyHealthPanel

The Biomechanical Study of Diseased Human Carotid, Femoral and Abdominal Aortic Tissue

ConditionVascular Diseases
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity Hospital of Limerick

About this trial

This cross-sectional study aims to ascertain the mechanical properties of human carotid/femoral atherosclerotic plaque and abdominal aortic aneurysm tissue and correlate tissue mechanics with novel blood-based biomarkers of cardiovascular calcification.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients with arterial plaque undergoing treatment where the plaque tissue will be surgically removed as per the usual peripheral endarterectomy procedure.

Able to provide informed consent.

Disqualifiers

Patients that are unable to give informed consent.

Seriously ill/unconscious patients.

Trial population

Patients eligible for peripheral endarterectomy of the carotid/femoral artery or abdominal aortic aneurysm surgery to remove artery blockage will be invited to take part in this study with no restrictions on patient type.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • No intervention.

    Other intervention

    No intervention.

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Calcification feature classification

Identification of particular calcification features of plaque tissue and their influence on mechanical properties which may help clarify the success of stenting in certain patient cohorts compared to others and elucidate the procedural risk of endovascular treatments in plaque with certain calcification types.

Time frame
10 years
2

Biomarker Analysis

Identification of novel biomarkers of vascular calcification could potentially be used as a predictive tool to highlight those at greatest risk of adverse peri-operative events, to allow for tailored medical treatment approaches and to stream-line patient care and improve patient outcomes.

Time frame
10 years

Secondary outcomes

1

Cardiovascular Health Critical Mass

To build a critical mass in cardiovascular health, an area of strategic importance for healthcare in Ireland.

Time frame
10 years

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University Hospital of Limerick

Lead sponsor

Source ClinicalTrials.gov
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