About this trial
Colonoscopic removal of polyps is an important and well-established tool in the prevention of colorectal cancers. However, high polyp recurrence rates after endoscopic resection, with resultant development of interval cancers, remains a problem; this most commonly stems from unrecognised incomplete polyp resection. Thus, a standardised endoscopic technique is needed that will allow endoscopists to consistently achieve a clear margin of resection. The investigators believe the Cap Assisted Resection Margin Assessment (CARMA) technique will address this problem. This novel technique focuses on a standardised assessment of the resection margin after endoscopic polypectomy utilising available standard high-definition video endoscopes with imaging features including narrow band imaging (NBI) and magnification endoscopy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
polyps less than 10mm which were resected under endoscopic view with a definite > 1mm clear margin
scar site recurrence polyps
polyps with endoscopic evidence of invasion
pedunculated polyps
Trial design
Single group
Treatments tested in this trial
CARMA technique
Procedure/SurgeryOnce standard polyp resection and assessment of the polypectomy site without magnification is completed, the CARMA technique will be applied. This will involve an assessment of the entire polypectomy margin using cap assisted magnification endoscopy with the ability to also use NBI (at the endoscopist's discretion) and documentation of any residual polyp noted.
Treatment groups
Trial outcomes
Primary outcomes
Rate of achieving a clear resection margin using the CARMA technique
Secondary outcomes
Sensitivity and specificity of the CARMA technique for residual polyp detection
Frequency of residual polyp without CARMA assessment
Incomplete resection rate with use of CARMA technique
Incomplete resection rate with use of the CARMA technique in polyps > 10mm with hot snare
Sponsors and contacts
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