This is an open-label, single-center, non-randomized study to assess the efficacy of Clostridium Butyricum Miyairi on the motor and non-motor symptoms of Parkinson's disease
Male or female over 20 years old, diagnosed with Parkinson's disease.
People with Parkinson's disease Dementia, or Lactose Intolerance
Single group
Miyarisan-BM (Clostridium Butyricum Miyairi)
Drugprobiotics
MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part 3
Part 3 of this scale assesses motor performance in 33 items. Each item is scored on a scale of 0 (normal) to 4 (severe), with a total score range of 0 to 132, and higher scores mean the patient's situation is worse.
Hamilton Depression Rating Scale (HAM-D)
This scale assesses non-motor symptoms in 17 items, the total scale value is 50 (Scores 0 to 7 mean normal, 8 to 13 mean mild depression, 14 to 18 mean moderate depression, 19 to 22 mean severe depression, and ≥23 mean very severe depression).
Hamilton Anxiety Scale (HAM-A)
This scale assesses non-motor symptoms in 14 items. Each item is scored on a scale of 0 (not present) to 4 (severe), with a total score range of 0-56, where ≤17 indicates mild anxiety severity, 18-24 indicate mild to moderate anxiety severity, 25-30 indicate moderate to severe anxiety severity, \>30 indicate severe anxiety.
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