1. To evaluate the clinical outcomes of ultrasound-guided thermal ablation and thyroid surgery for the treatment of papillary thyroid carcinoma; 2. To develop and validate a artificial intelligence model to predict the outcomes of ultrasound-guided thermal ablation in the treatment of papillary thyroid carcinoma;
patients age between 18 and 80 year old, both sex
papillary thyroid carcinoma confirmed by core-needle biopsy or fine-needle aspiration
the largest diameter ≤2.0 cm
no clinical or imaging evidences of extrathyroidal extension, lymph node metastasis and distant metastasis on ultrasound, nech and chest CT
patients with convincing evidence of aggressive papillary thyroid carcinoma or other type of thyroid cancer by biopsy
history of neck radiation
history of thyroid surgery
coagulation disorder
patients with low-risk papillary thyroid carcinoma who choose surgery or thermal ablation
Cohort
Prospective
thyroid surgery
Procedure/Surgerythyroid lobectomy
ultrasound-guided thermal ablation
Procedure/Surgeryradiofrequency ablation; microwave ablation or laser ablation
rate of disease progression
cervical lymph node metastases, recurrent tumors and persistent tumors
Rate of complications
surgery or ablation complications
Rate of tumor disappearance
complete disappearance of ablated tumor on ultrasound and contrast-enhanced ultrasound
Click on the lead sponsor to view all of their trials.
