The Clonal Hematopoiesis & Inflammation in Vasculature Registry and Biorepository
ConditionClonal Hematopoiesis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorVanderbilt-Ingram Cancer Center
About this trial
This study will investigate the association between clonal hematopoiesis and other conditions. Clonal hematopoiesis (CH) refers to the mutations in a person's stem cells which commonly affect people as they get older. These mutations have notably been linked to increased risk of certain cancers as well as increased risk of heart disease.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patient greater than or equal to 18 years old at time of consent
Able to provide informed consent
Idiopathic cytopenia (ICUS) or idiopathic cytoses (elevated blood counts without disease or explanation); clonal cytopenia of undetermined significance (CCUS), clonal hematopoiesis of indeterminate potential (CHIP) or individuals at higher risk for clonal hematopoiesis (ex. patients with known diagnosis of solid tumors or cardiovascular disease)
Disqualifiers
Unable to provide consent
Diagnosis of active hematologic malignancy. For example, a diagnosis of CMML, AML, MDS, MPN; History of hematologic malignancy is NOT exclusionary if in complete remission (e.g. previous myeloma or lymphoma)
Trial population
Adults \>/= 18 years old with a mutation known to cause clonal hematopoiesis or at a higher risk of having a clonal hematopoiesis mutation.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Blood collection
Other interventionBlood will be taken from participants already undergoing blood collection
Saliva collection
Other interventionUndergo saliva collection
Bone marrow collection
Other interventionBone marrow will be taken from participants already undergoing bone marrow collection
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
CHIVE Registry
Aggregate data will be utilized to better understand the association between clonal hematopoiesis and other conditions
Time frame
Up to approximately 120 months2
CHIVE Biorepository
Number of biological samples collected and stored (Blood, saliva, bone marrow) for future studies.
Time frame
Up to approximately 120 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov