The Cohort Construction Project of Peking University Third Hospital
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorPeking University Third Hospital
About this trial
The specific construction goals for this period include enrolling 100,000 individuals for dynamic follow-up, perfecting the biobank by collecting biological samples from 20,000 individuals, and gathering health questionnaire information from 30,000 people. The near-term goals emphasize the use of health check-up data combined with advanced artificial intelligence technologies to build disease prediction models and explore the association between retinal photographs and overall health status, which will assist in early screening and personalized interventions for high-risk populations. The medium- to long-term goals focus on biological age-related research, utilizing telomere length and multi-omics technologies to assess the differences between biological age and chronological age and analyze their key influencing factors. Data collection will be implemented through the health check-up centers of multiple campuses of PUTH.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥ 18 years. Participants must be from group health examination populations who have undergone at least two consecutive health examinations at our Physical Examination Center.
Disqualifiers
Failure to provide informed consent. Incomplete data, including incomplete health examination self-administered questionnaires.
Trial population
The study population consists of individuals who voluntarily undergo health examinations at the Physical Examination Center of Peking University Third Hospital. Participants are recruited from group health examination populations (including employees from functional community units such as government agencies, schools, and enterprises) who have undergone at least two consecutive health examinations at the center. The study includes both retrospective and prospective participants, with long-term follow-up and biospecimen collection (serum) stored in the hospital's biobank.
Trial design
Design model
Cohort
Time perspective
Other
Treatments tested in this trial
observational study
Other interventionThis is an observational study designed to investigate the mental health status and its influencing factors in the general physical examination population. No interventions are assigned to participants based on a protocol.
Treatment groups
100,000 Participants
are divided into 1 treatment groupGroup A: Functional Community Health Examination Cohort1 intervention
Trial outcomes
Primary outcomes
1
Systolic and Diastolic Blood Pressure
Blood pressure will be measured using a standardized mercury sphygmomanometer after at least 5 minutes of rest in a seated position. Both systolic blood pressure (SBP) and diastolic blood pressure (DBP) will be recorded.
Time frame
through study completion, an average of 3 year2
Fasting Lipid Profile (Total Cholesterol, Triglycerides, LDL-C, and HDL-C)
Venous blood samples will be collected after at least 8 hours of overnight fasting. Serum levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) will be measured using an automated biochemical analyzer at the central laboratory of Peking University Third Hospital.
Time frame
through study completion, an average of 3 year3
Fasting Blood Glucose (FBG)
Fasting venous blood samples will be collected after at least 8 hours of overnight fasting. Serum glucose levels will be measured using an automated biochemical analyzer at the central laboratory of Peking University Third Hospital.
Time frame
through study completion, an average of 3 year4
Glycated Hemoglobin (HbA1c)
Fasting venous blood samples will be collected and analyzed using high-performance liquid chromatography (HPLC) at the central laboratory of Peking University Third Hospital. HbA1c reflects average blood glucose levels over the previous 2 to 3 months.
Time frame
through study completion, an average of 3 yearSecondary outcomes
1
BMI
Body composition will be measured using bioelectrical impedance analysis (BIA) or dual-energy X-ray absorptiometry (DXA) at the Physical Examination Center of Peking University Third Hospital. Body mass index (BMI) will be calculated as weight in kilograms divided by height in meters squared (kg/m²).
Time frame
through study completion, an average of 3 year2
Body Fat Percentage
Body composition will be measured using bioelectrical impedance analysis (BIA) or dual-energy X-ray absorptiometry (DXA) at the Physical Examination Center of Peking University Third Hospital. Body fat percentage (BFP) will be reported as a percentage (%).
Time frame
through study completion, an average of 3 year3
Visceral Fat Area
Body composition will be measured using bioelectrical impedance analysis (BIA) or dual-energy X-ray absorptiometry (DXA) at the Physical Examination Center of Peking University Third Hospital. Visceral fat area (VFA) will be reported in square centimeters (cm²).
Time frame
through study completion, an average of 3 year4
Skeletal Muscle Mass
Body composition will be measured using bioelectrical impedance analysis (BIA) or dual-energy X-ray absorptiometry (DXA) at the Physical Examination Center of Peking University Third Hospital. Skeletal muscle mass (SMM) will be reported in kilograms (kg).
Time frame
through study completion, an average of 3 yearOther outcomes
1
Thyroid Function Panel
Fasting venous blood samples will be collected and analyzed using an automated chemiluminescence immunoassay analyzer at the central laboratory of Peking University Third Hospital. Key parameters include thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4). Additional parameters (e.g., total T3, total T4, anti-thyroglobulin antibody \[TG-Ab\], and anti-thyroid peroxidase antibody \[TPO-Ab\]) may be measured as clinically indicated.
Time frame
Measured at baseline and at each annual health examination visit2
Inflammatory Biomarker Panel
Fasting venous blood samples will be collected and analyzed at the central laboratory of Peking University Third Hospital. The inflammatory biomarker panel includes high-sensitivity C-reactive protein (hsCRP) measured by immunoturbidimetry, and a panel of serum cytokines (including but not limited to IL-6, TNF-α, IL-10, and IL-17A) measured using a multiplex immunoassay system. Additional inflammatory markers such as white blood cell count (WBC) and ferritin will also be assessed. All measurements will be performed following standardized protocols.
Time frame
Measured at baseline and at each annual health examination visitSponsors and contacts
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Source ClinicalTrials.gov