The Correlation Between hs CRP TG Triglycerides Glucose Index in NAFLD and Liver Fibrosis

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-85
SponsorAssiut University

About this trial

The Correlation between hs CRP TG triglycerides Glucose index in NAFLD and liver fibrosis

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adults ≥18 years

Available fasting labs: TG, fasting glucose, hs-CRP

Valid liver assessment by VCTE (FibroScan LSM) and CAP or ultrasound-based steatosis assessment

Disqualifiers

1- Significant alcohol intake (define using your local standard; commonly sex-specific thresholds) 2- Viral hepatitis (HBsAg positive and/or HCV RNA positive) 3- Other chronic liver diseases (autoimmune hepatitis, hemochromatosis, Wilson's, etc.) 4- Pregnancy

Trial population

Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent chronic liver disease in the world, affecting one-fourth of the global population, and represents a serious public health issue. NAFLD encompasses a broad spectrum of liver abnormalities, ranging from simple hepatic steatosis, which is thought to be benign, to non-Alcoholic Steatohepatitis (NASH) without fibrosis and progressing to fibrotic NASH. The evolution of liver fibrosis results in irreversible architectural changes of the liver and can progress to Hepatocellular Carcinoma (HCC) (Sheka et al., 2020; Zhou et al., 2025). NAFLD is associated with an increased risk of systemic metabolic disorders, such as hyperuricemia, hyperlipidemia, IR, and hyperglycemia. These metabolic disorders, in combination with NAFLD, contribute to the risk of developing extrahepatic malignancies and cardiovascular diseases, which are the main causes of extrahepatic mortality (Li et al., 2022). High-sensitivity C-reactive protein

Trial design

Design model

Other

Time perspective

Cross-sectional

Treatments tested in this trial

  • • Fasting triglycerides (TG) • Fasting plasma glucose • High-sensitivity C-reactive protein (hs-CRP) • Liver enzymes (ALT, AST, GGT) • Platelet count • HbA1c • Lipid profile (total cholesterol, HDL-C,

    Other intervention

    Participants will be instructed to fast for 8-12 hours before blood sampling. Venous blood samples will be collected in the morning and analyzed in a certified laboratory for: * Fasting triglycerides (TG) * Fasting plasma glucose * High-sensitivity C-reactive protein (hs-CRP) * Liver enzymes (ALT, AST, GGT) * Platelet count * HbA1c * Lipid profile (total cholesterol, HDL-C, LDL-C)

Treatment groups

96 Participants
are divided into 1 treatment group
Group A: Participants will be instructed to fast for 8-12 hours before blood sampling. Venous blood samples w1 intervention

Trial outcomes

Primary outcomes

1

Presence of NAFLD (defined by CAP ≥248 dB/m after exclusion of secondary causes).

Time frame
1Year

Secondary outcomes

Other outcomes

Sponsors and contacts

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