CAIS-MT is a single-center, prospective cohort study, to evaluate the correlation between outcomes of endovascular treatment(EVT) and intracranial artery calcification(IAC) in patients with acute ischemic stroke due to large or medium vessel occlusion.
Male or non-pregnant women with acute stroke symptoms aged over 18 years.
Occlusion of the intracranial internal carotid artery, the middle cerebral artery, the anterior cerebral artery, the posterior cerebral artery, basilar artery and intracranial vertebral artery confirmed by CT, MR angiography, or digital subtraction angiography.
No absolute contraindication to iodinated contrast media.
Planned treatment with EVT by clinical care team.
Acute ischemic stroke occurs over 24 hours of time last known well.
Neurologic deficits caused by diagnoses other than ischemic stroke, such as intracerebral hemorrhage, subarachnoid hemorrhage, or intracranial tumors.
With other underlying factors leading to IAC, such as hyperthyroidism, end-stage renal disease, long-term oral intake of vitamin K antagonist(Warfarin), chronic vitamin D deficiency or overdose, persistent hypomagnesemia, persistent hypercalcemia, persistent hyperphosphatemia and high oral calcium intake.
Lack of non-contract CT images on admission and significant artifacts in CT images preventing IAC measurement.
Patients with a diagnosis of acute ischemic stroke due to large or medium vessel occlusion, who are enrolled at Zhujiang Hospital and meet the indication for EVT.
Cohort
Prospective
Not listed
Proportion of patients with a adverse functional outcome at 3 months
Modified Rankin Scale(mRS) score \> 2
Proportion of patients without disability at 3 months
mRS score 0-1
Proportion of patients with functional independence at 3 months
mRS score 0-2
Proportion of patients ambulatory or bodily needs-capable or better at 3 months
mRS score 0-3
Change of the NIHSS score at 24 hours from baseline
Change of the NIHSS score at 24 hours from baseline
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