The Diagnostic Value of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorPeking University Third Hospital
About this trial
The goal of this observational study is to quantitatively assess the renal microcirculation changes by contrast-enhanced ultrasound (CEUS) and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore the diagnostic value of CEUS in critically ill acute kidney injury.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age>18 years old
First admission to ICU < 24h after admission and expected ICU stay ≥48 hours
Acute kidney injury risk factors (KDIGO 2012)
Contrast-enhanced ultrasound
Disqualifiers
Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment
Kidney transplantation or renal malignancy
Terminal stage of malignant tumor
Pregnancy
Trial population
Through literature review, the latest meta-analysis results showed that the area under the curve of CEUS parameters for diagnosing AKI was 0.84 and the width of the confidence interval was 0.22. When α=0.05, the sample size N=54 was obtained by PASS software. Considering the 10% shedding rate, 60 patients were expected to be enrolled in this study.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Contrast-enhanced Ultrasound
Diagnostic testPatients with acute kidney injury high risk factors (KDIGO 2012) will undergo a contrast-enhanced ultrasound within 24 hours of admission to the ICU
Treatment groups
60 Participants
are divided into 2 treatment groupsGroup A: Patients with acute kidney injury (AKI)1 intervention
Group B: Patients without AKI1 intervention
Trial outcomes
Primary outcomes
1
Acute kidney injury (according to KDIGO 2012 criteria)
Acute kidney injury occur or not
Time frame
Through study completion, an average of 7 daysLocations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: