The Effect of Aerobic Exercise on the Irisin/Klotho/Sirtuin-1/BDNF Axis
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age18-45
SponsorCemre Didem Eyipinar
About this trial
The purpose of this study is to investigate the effects of an acute aerobic exercise on irisin, klotho, sirtuin-1, and BDNF levels in the healthy adults. The findings will help understand the physiological impacts of exercise on these biomarkers.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Being between the ages of 18 and 45
Being in good health and having no diagnosis of any chronic disease
Not having taken regular medication within the last 4 weeks
Voluntary participation and providing written informed consent
Disqualifiers
Individuals with a history of cardiovascular, endocrine, metabolic, or renal disease
Individuals with a history of active infection, musculoskeletal injury, or severe disability
Individuals with any medical condition that might prevent participation in exercise
Individuals unable to regularly participate in the exercise protocol throughout the study
Trial design
Design model
Parallel
Treatments tested in this trial
Aerobic exercise
BehavioralAcute aerobic exercise until exhaustion
Treatment groups
26 Participants
are divided into 2 treatment groupsGroup A: Experimental GroupExperimental treatment 1 intervention
Group B: Control GroupNo intervention 0 interventions
Trial outcomes
Primary outcomes
1
Salivary Irisin Level
Irisin concentration will be determined from a saliva sample using the ELISA technique.
Time frame
Baseline- immediately after exercise and 1 hours after exercise2
Salivary Klotho Level
Klotho concentration will be determined from a saliva sample using the ELISA technique.
Time frame
Baseline- immediately after exercise and 1 hours after exercise3
Salivary Sirtuin Level
Sirtuin concentration will be determined from a saliva sample using the ELISA technique.
Time frame
Baseline- immediately after exercise and 1 hours after exercise4
Salivary BDNF Level
BDNF concentration will be determined from a saliva sample using the ELISA technique.
Time frame
Baseline- immediately after exercise and 1 hours after exerciseSecondary outcomes
1
Saliva Flow Rate
It will be calculated individually by dividing the weight of the saliva collected within one minute by the duration.
Time frame
Baseline- İmmediately after exercise and 1 hour after exerciseSponsors and contacts
Click on the lead sponsor to view all of their trials.
Cemre Didem Eyipinar
Lead sponsor
University of Gaziantep
Sponsor institution
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: