The Effect of Different Doses of Dexamethasone on Post Spinal Anesthesia Shivering

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-55
SponsorAssiut University

About this trial

The precise etiology of post-spinal anesthesia shivering (PSAS) is not fully understood. The incidence ranges between 20 to 80%. Heat loss, reduced sympathetic tone and pyrogen release are termed as the main causes of intra/postoperative shivering.

The redistribution of heat from the core to the periphery of the body is facilitated by the vasodilatation associated with neuraxial anesthesia. Shivering causes tachycardia, lactic acidosis, hyperalgesia at the site of surgery, releases catecholamines, increases oxygen demand, and increases the risk of hypoxemia. \[1\]\[3\] The most common causes of shivering include fever, shivering with spinal anesthesia movement disorders, post-anesthetic shivering, fear, excitement, stress, tremors, low blood sugar, anxiety, and shivering. Shivering with spinal anesthesia is an involuntary, oscillatory muscular activity that significantly increases metabolic heat production, potentially reaching up to 600% above the basal metabolic level.

Post-spinal shivering is one of the main sources of discomfort for patients recovering from surgery. Furthermore, it worsens wound pain and impedes electrocardiographic monitoring.

Prophylactic intravenous administration of dexamethasone has been currently used for controlling intra-operative and post spinal anesthesia shivering. Dexamethasone's anti-inflammatory effects may thereby lessen post-anesthesia shivering by reducing the gradient between skin and core body temperatures.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

ASA physical status I-II.

Both sexes.

Age: 21-55 years old.

Scheduled for lower limb orthopedic surgery.

Disqualifiers

ASA physical status more than II.

History of corticosteroid therapy or allergic reaction to any of the medication used in the study

Patients with cognitive impairment.

Pregnancy.

Trial design

Design model

Factorial

Treatments tested in this trial

  • Dexamethasone 0.1mg/kg

    Drug

    On incidence of Shivering after spinal anaethesia

  • Dexamethasone 0.3mg/kg

    Drug

    On incidence of Shivering after spinal anaethesia

Treatment groups

150 Participants
are divided into 2 treatment groups
Group A: Group AActive comparator 1 intervention
Group B: Group BActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

severity of PSAS

Bedside Shivering Assessment Scale (BSAS) was used to grade the severity: Grade 1 (zero points): No shivering Grade 2 (1 point): mild shivering that is limited to the neck and thorax may not be detected and may only be detected by palpation or as an artefact on ECG Grade 3 (2 points): Moderate: Intermittent upper extremity involvement plus/minus thorax Grade 4 (3 points): Severe: prolonged trembling of the upper or lower extremities or widespread shivering.

Time frame
60 minutes after operation

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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