The Effect of High-Intensity Short-Duration Exercise Versus Moderate-Intensity High-Volume Exercise on Glucose Control

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of California, San Francisco

About this trial

This study will be conducted as a prospective, randomized crossover trial evaluating non-diabetic and pre-diabetic adults ($n=12$) continuously monitored with Dexcom G7 continuous glucose monitors over an 11-day period. Participants will complete two distinct exercise protocols in a randomized sequence: five consecutive days of Zone 2 aerobic exercise and a single session of high-intensity interval training (HIIT). Primary outcome metrics will focus on mean glucose levels and time in range (TIR, defined as $\\le 120\\text{ mg/dL}$) recorded throughout each active exercise block and its associated recovery window. To evaluate the comparative efficacy of the two modalities, paired within-subject differences will be statistically analyzed against pre-specified non-inferiority margins set at $3\\text{ mg/dL}$ for mean glucose, as well as a primary $3$-point and secondary $5$-point margin for time in range.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Crossover

Treatments tested in this trial

  • High Intensity Interval Training

    Other intervention

    The Norwegian 4x4: The workout begins with a 5-to-10-minute warm-up, followed by four separate 4-minute high-intensity intervals where you push your body to 85%-95% of your maximum heart rate (roughly an 8 or 9 out of 10 effort level, where you are breathing too heavily to speak full sentences). Each intense "push" is interspersed with a 3-minute active recovery period of low-intensity movement-such as walking or light cycling-to let your heart rate drop back down to roughly 60%-70% of its maximum before starting the next round.

  • Moderate Intensity aerobic training

    Other intervention

    45 minutes of zone 2 training for five consecutive days

Treatment groups

12 Participants
are divided into 2 treatment groups
Group A: Moderate Intensity ExerciseExperimental treatment 1 intervention
Group B: High Intensity ExerciseActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Mean Glucose Concentration

Average glucose level recorded by continuous glucose monitor (CGM) across the exercise intervention block and its subsequent recovery window.

Time frame
Measured continuously over each 5-day exercise/recovery block within the 11-day monitoring period.
2

Time in Range (TIR)

Percentage of time spent with sensor glucose values under 120mg/dL during the active exercise block and its recovery window.

Time frame
Measured continuously over each 5-day exercise/recovery block within the 11-day monitoring period.

Secondary outcomes

Other outcomes

Sponsors and contacts

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