The Effect of Hyperoxia on Ventilation During Recovery From General Anesthesia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorStanford University
About this trial
In this randomized-controlled trial the investigators will examine the effect of oxygen supplementation on the recovery of breathing for 90 minutes in the immediate post-anesthesia period starting from extubation of the trachea.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
American Society of Anesthesiologists (ASA) physical status I-III
Body mass index (BMI) less than 40 kg/m2
Scheduled to undergo robotic-assisted radical laparoscopic nephrectomy or prostatectomy.
Disqualifiers
Patients with a diagnosis of chronic obstructive pulmonary disorder (COPD), severe neurological, cardiopulmonary, psychiatric, or untreated thyroid disorder
Chronic pain condition that is being treated with opioids
Patients with a hematocrit lower than 30% at the end of surgery, or those with an excessive blood loss, requiring transfusion of blood products during surgery.
Trial design
Design model
Parallel
Treatments tested in this trial
Oxygen Gas for Inhalation
Other interventionOxyhemoglobin saturation (SpO2) higher than 96% vs SpO2 between 90% and 94%.
Treatment groups
60 Participants
are divided into 2 treatment groupsGroup A: "Conservative O2 Supplementation"Active comparator 1 intervention
Group B: "Liberal O2 Supplementation"Experimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Transcutaneous partial pressure of carbon dioxide (TcPCO2)
The cumulative segment of time during which the transcutaneous partial pressure of carbon dioxide (TcPCO2: primary outcome) will exceed an upper limit of 45 mmHg (i.e., TcPCO2 \> 45 mmHg)
Time frame
Ninety -minute period beginning immediately post-anesthesia.Secondary outcomes
1
Apnea / hypopnea index (AHI)
The number of apnea /hypopnea episodes detected using respiratory inductance plethysmography and nasal pressure.
Time frame
Ninety -minute period beginning immediately post-anesthesia.Sponsors and contacts
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Source ClinicalTrials.gov