This study investigates the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization (IVF) outcomes in women over 35 years old. In the study group, patients will receive melatonin supplementation for at least two months prior to their IVF cycles. Cumulus cells will be collected after oocyte retrieval, and IVF outcomes will be assessed.
Age 35-45 years
BMI 18-30 kg/m2
planning to undergo IVF cycles
Primary ovarian insufficiency
history of oophorectomy
receiving oocyte donation
Chromosome anomaly
Parallel
Melatonin
Dietary supplementIn the study group, patients will receive melatonin supplementation for at least two months prior to IVF cycles
Live birth rate (%)
a viable infant after 24 weeks of gestation
oxygen consumption rate of mitochodria (%)
to assess mitocondrial function in cumulus cells
mRNA levels of cumulus cell genes
to assess cumulus cells gene expression analysis
Clinical pregnancy rate (%)
the presence of a fetal heartbeat detected via transvaginal sonography at 6-7 weeks of gestation
Ongoing pregnancy rate (%)
the continuation of the pregnancy beyond 12 weeks of gestation
Amount of ATP production (moles/min) of mitochodria
to assess mitocondrial function in cumulus cells
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