The Effect of Morning vs Evening Aerobic Exercise Training on Cardiac Remodeling and Function Improvement in Patients After ST Elevation Myocardial Infarction

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age17-75
SponsorRenJi Hospital

About this trial

The aim of the study was to intervene in the Aerobic exercise time of patients with STEMI and to explore the optimal exercise time for STEMI patients

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Between 18 and 75-years-old;

Typical symptoms of acute myocardial infarction within 24 hours, with ST segment elevation of ≥1mm in two consecutive leads on electrocardiogram

After receiving complete revascularization treatment

Cardiac function grading I to II without any other serious complications

Disqualifiers

Patients with unstable angina

severe symptomatic congestive heart failure detectable myocardial ischemia

valvular disease requiring surgery

severe ventricular arrhythmias

Trial design

Design model

Parallel

Treatments tested in this trial

  • Morning aerobic exercise

    Other intervention

    Patients were randomly assigned to morning aerobic exercise training for a 12-week outpatient training program that included a combination of warm-up, aerobic, and relaxation exercises three times a week. Each class consists of 10 minutes of warm-up training, 40 minutes of aerobic training and 10 minutes of relaxation training. The intensity of aerobic exercise training will be personalized. According to the guidance of relevant guidelines, the exercise intensity of patients will be determined according to the results of their first cardiopulmonary exercise experiment, and the exercise load will be gradually increased according to the exercise program until the predetermined goal is reached. Patient fatigue levels will be monitored throughout the exercise using the borg scale.

  • Evening aerobic exercise

    Other intervention

    Patients were randomly assigned to evening aerobic exercise training for a 12-week outpatient training program that included a combination of warm-up, aerobic, and relaxation exercises three times a week. Each class consists of 10 minutes of warm-up training, 40 minutes of aerobic training and 10 minutes of relaxation training. The intensity of aerobic exercise training will be personalized. According to the guidance of relevant guidelines, the exercise intensity of patients will be determined according to the results of their first cardiopulmonary exercise experiment, and the exercise load will be gradually increased according to the exercise program until the predetermined goal is reached. Patient fatigue levels will be monitored throughout the exercise using the borg scale.

Treatment groups

201 Participants
are divided into 3 treatment groups
Group A: Morning rehabilitation groupExperimental treatment 1 intervention
Group B: Evening rehabilitation groupExperimental treatment 1 intervention
Group C: Control groupNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

left ventricle ejection fraction

Use cardiac ultrasound system to measure left ventricle ejection fraction

Time frame
at baseline,at the sixth week, and after the 12th week of training or follow-up

Secondary outcomes

1

Oxygen consumption

Patients will be submitted to cardiopulmonary exercise testing on a bicycle, using the modified Bruce protocol. Expired gases will be continuously collected throughout exercise and analyzed for ventilatory volume (VE) and for oxygen (O2) and carbon dioxide (CO2) content, using dedicated analyzers. The investigators will assess exercise capacity mainly by measuring anaerobic threshold oxygen consumption and peak oxygen consumption.

Time frame
at baseline,at the sixth week, and after the 12th week of training or follow-up
2

Endothelial Function

Use high-resolution Doppler duplex ultrasound e equipment to analysis Baseline arterial diameter (mm), peak arterial diameter (mm).

Time frame
at baseline,at the sixth week, and after the 12th week of training or follow-up
3

Skeletal muscle and fat mass

Determined by multifrequency BIA using an InBody 770 analyzer (InBody Co., Ltd), that estimate skeletal muscle mass, Body fat mass, distribution of lean body mass and ratio of segmental lean mass.

Time frame
at baseline,at the sixth week, and after the 12th week of training or follow-up
4

Cardiac structure

Use cardiac ultrasound system to measure left ventricular end-diastolic/end-systolic internal diameter, and left ventricular anterior wall thickness.

Time frame
at baseline,at the sixth week, and after the 12th week of training or follow-up

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.