Health TrialsbyHealthPanel

The Effect of Physical Activity on Knee Osteoarthritis, Pain and Gait

ConditionOsteoarthritis (OA) of the Knee
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAnglia Ruskin University

About this trial

Knee osteoarthritis, a chronic musculoskeletal disease, is the most prevalent type of osteoarthritis and the leading cause of disability and major healthcare costs worldwide. The pathogenesis of the disease is not fully understood and there are few non-invasive disease-modifying therapies available to patients. Therefore, there is a critical need to enhance therapeutic interventions, which requires improvement of our understanding of knee osteoarthritis pathogenesis.

Increasing evidence suggests that physical activity and exercise training are cost-effective and widely available interventions for the treatment of knee osteoarthritis, however, consideration of type of physical activity and optimal exercise modality are needed to reduce pain, improve gait, knee joint function, stiffness, and muscle weakness in individuals with knee osteoarthritis.

The aim of this pilot clinical trial is to compare individuals with knee osteoarthritis who have not exercised with individuals that have performed retro walking exercise chosen from the systematic review and survey we have conducted previously to reduce pain and improve gait.

Non-linear analyses will be performed to determine the effects of exercise intervention on gait biomechanics and stability of movement in these patients. These findings may form a basis for recommendations of exercise/physical activity interventions for the benefits of patients with knee osteoarthritis including pain reduction, mobility improvement and gait modification.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Male and female

Any ethnicity

Adults over 18 years old

Meet the UK guidelines for physical activity supported by NICE (National Institute for Health and Care Excellence) and NHS (able to exercise if it is safe with regular breaks)

Disqualifiers

Any musculoskeletal injury

Any conditions known to affects gait (e.g. Parkinson's disease or stroke)

Any surgical intervention in the previous 12 months on lower limbs

Surgical replacement of hip or knee joints

Trial design

Design model

Parallel

Treatments tested in this trial

  • Retro walking (backwards walking) on a treadmill

    Other intervention

    Prior to the intervention participants will be made familiar with retro walking on the treadmill. The exercise will consist of a forward walking for 5min on the treadmill for warm-up followed by retro walking for 10min and a cool-down for 5min. Participants will be instructed to increase their retro walking time up to 30min if the pain sensation continuously was reduced (pain scores \< 3 numerical rating scale). The comfortable speed of the retro walking will be determined by the participant under supervision of the researchers. No slopes or inclination will be used in this study for participant safety. In the warm-up and cool-down sessions participants will be asked to perform muscle stretch, ankle toe movements and heel raise exercises.

Treatment groups

44 Participants
are divided into 2 treatment groups
Group A: ExerciseExperimental treatment 1 intervention
Group B: ControlNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Knee function and associated frequency and severity of pain

Participants' opinion about their own knee function and associated problems will be assessed through self-administered and validated questionnaire Knee Injury and Osteoarthritis Outcome Score (KOOS). KOOS questionnaire designed to collectively evaluate and measure five outcomes in individuals with knee osteoarthritis including: Pain: Frequency and severity of knee pain. Symptoms: Swelling, grinding, stiffness, and range of motion issues. Activities of Daily Living (ADL): Difficulty with physical tasks like stairs, rising from a seat, or getting in and out of a car. Sports and Recreation Function: The ability to perform higher-level physical activities, such as running, squatting, or playing sports. Quality of Life (QOL): Knee-related lifestyle limitations and personal awareness of the joint.

Time frame
Baseline or Day 1 and end of study at 6 weeks

Secondary outcomes

1

Pain intensity

A standardised tool numeric pain rating scale (NPRS) will be used to measure a participants' pain intensity. It is an 11-point scale ranging from 0 to 10. 0: Represents "no pain" whereas 10: Represents the "worst imaginable pain". Participants can state their number verbally or circle it on a chart.

Time frame
Baseline or Day 1 up to 6 weeks
2

The gait biomechanics - change from baseline in spatiotemporal parameter walking speed at 6 weeks

Spatiotemporal parameter walking speed (velocity, meters/sec) will be assessed using VICON motion capture analysis system.

Time frame
Baseline or Day 1 and end of study at 6 weeks
3

The gait biomechanics - change from baseline in spatiotemporal parameter cadence at 6 weeks

Spatiotemporal parameter cadence (steps/min) will be assessed using VICON motion capture analysis system.

Time frame
Baseline or Day 1 and end of study at 6 weeks
4

The gait biomechanics - change from baseline in spatiotemporal parameter stride/step length at 6 weeks

Spatiotemporal parameter stride/step length (meters or cm) will be assessed using VICON motion capture analysis system.

Time frame
Baseline or Day 1 and end of study at 6 weeks

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Anglia Ruskin University

Lead sponsor

Cambridge University Hospitals NHS Foundation Trust

Collaborator

Nuffield Health

Collaborator

Source ClinicalTrials.gov

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