The Effect of Repetitive Transcranial Magnetic Stimulation for Internet Gaming Disorder
ConditionInternet Gaming Disorder
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-30
SponsorJin-tao Zhang
About this trial
This study aims to investigate the intervention effects of navigated repetitive transcranial magnetic stimulation (rTMS) on craving regulation in individuals with internet gaming disorder (IGD). The primary objectives include: (1) examining the impact of navigated rTMS over the dorsolateral prefrontal cortex (DLPFC) on the gaming cravings, and craving regulation capacity; and (2) exploring the potential neural mechanisms by which rTMS over the DLPFC improves craving intensity, and craving regulation ability.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
DSM-V gaming disorder >5 and scored ≥ 50 on a revised version of Young's online Internet addiction test；
spent more than 50% of their online time gaming；
engagement in one of four popular Internet game (Arena of Valor,Genshine, LOL, FPS) for over 20 hours per week for at least 1 year.
Disqualifiers
current or history of use of illegal substances and gambling;
current or history of psychiatric or neurological illness;
current use of psychotropic medications;
cognitive impairment as assessed by the Mini-International Neuropsychiatric Interview；
Trial design
Design model
Crossover
Treatments tested in this trial
real rTMS on the dlPFC
Other interventionDuring real rTM session, participants will perform the regulation of craving (ROC). In the rest phase, participants need to relax and rest. In the ROC task, participants will regulate craving elicited by gaming pictures using cognitive reappraisal. During the task, reaction times (RTs) and craving scores wil be recorded.
Sham (No Treatment)
Other interventionDuring the sham rTMS session, participants will perform the regulation of craving (ROC). In the ROC task, participants will regulate craving elicited by gaming pictures using cognitive reappraisal. During the task, reaction times (RTs) and craving scores wil be recorded.
Treatment groups
35 Participants
are divided into 2 treatment groupsGroup A: real rTMS on the dlPFCExperimental treatment 1 intervention
Group B: sham rTMS on the dlPFCSham comparator 1 intervention
Trial outcomes
Primary outcomes
1
Change in craving scores in the Cue-Reactivity(CR) task
Comparing the participants who reported craving scores for the game stimuli in the unregulated condition and in the regulated condition in the CR task conducted separately during real rTMS and sham rTMS. Higher scores mean higher craving.
Time frame
Approximately 10 minutes during real rTMS condition and sham rTMS2
Changes in the DLPFC and craving-related brains (striatum, amygdala) activities in the ROC task following rTMS and sham rTMS
This study will compare the changes in DLPFC activity during the ROC task after real rTMS and sham rTMS. In addition, craving-related brain regions (striatum and amygdala) are also concerned.
Time frame
Approximately 14 minutes - 29 minutes after real rTMS and sham rTMS3
Alterations in the functional connectivity between the DLPFC and other brain regions in the ROC task following rTMS and sham rTMS
The present study compares the alterations in functional connectivity between the DLPFC and other brain regions (especially those related to reward) after real TMS and sham TMS.
Time frame
Approximately 14 minutes - 29 minutes after real rTMS and sham rTMSSecondary outcomes
1
Changes in ReHo and fALFF/ALFF in resting-state following rTMS and sham rTMS
This study will compare changes in brain regional homogeneity (ReHo) and the fractional amplitude of low-frequency fluctuations (fALFF/ALFF) during the resting state following real rTMS and sham rTMS, particularly in the DLPFC and reward-related brain regions. These measures reflect the effects of rTMS on participants.
Time frame
5 minutes-13 minutes after real rTMS and sham rTMS2
The DLPFC-based functional connectivity alterations during resting-state fMRI
Use seed -based functional connectivity method to explore the alterations in the functional connectivity between the DLPFC and other brain regions, particularly reward-related areas, will be examined.
Time frame
5 minutes-13 minutes after real rTMS and sham rTMS3
The intra- and inter-connectivity within brain networks during resting-state fMRI
Graph-theoretic analysis will be used to depict alterations in brain networks following real rTMS and sham rTMS. The present study also concern the changes in intra- and inter-connectivity within brain networks (including executive control systems, reward systems, and default networks) after real rTMS and sham rTMS.
Time frame
5 minutes-13 minutes after real rTMS and sham rTMSSponsors and contacts
Click on the lead sponsor to view all of their trials.
Jin-tao Zhang
Lead sponsor
Beijing Normal University
Sponsor institution
Zi-Liang Wang, Medical Ethics Committee of Zhenjiang Mental Health Center
Collaborator
Source ClinicalTrials.gov