The study aims to assess the effect of superselective adrenal arterial embolization on vascular endothelial function in patients with primary aldosteronism based on brachial artery flow-mediated relaxation
(1)Aged 18-75 years, males and females;
(2)Blood pressure ≥ 140/90 mmHg on at least three non-same-day office visits without antihypertensive medication or 24-hour ambulatory blood pressure averaging >130/80 mmHg throughout the day or averaging >135/85 mmHg during the day;
(3)Primary aldosteronism was diagnosed in accordance with the 2016 international society of Endocrinology clinical guidelines after strict drug elution;
(4)Contraindications to spironolactone-free administration;
(1)Secondary hypertension of other causes;
(2)Pregnant women or those who have a fertility plan in the next year;
(3)Glomerular filtration rate EGFR < 45 ml/min/1.73m²;
(4)History of severe contrast allergy;
Patients who were diagnosed with primary aldosteronism and underwent adrenal vein sampling at the Second Affiliated Hospital of Nanchang University.
Cohort
Prospective
Super selective adrenal artery embolization
Procedure/SurgerySuperselective adrenal arterial embolization is an operation to inject embolic agent into adrenal artery through catheter to embolize part of adrenal gland, so as to reduce the secretion of adrenal hormone and reduce blood pressure.
Spironolactone
DrugAldosterone receptor antagonists are recommended by guidelines for the treatment of bilateral primary aldosteronism.
endothelial function
Brachial artery endothelial function measured by flow-mediated dilation(FMD)
endothelial function
Brachial artery endothelial function measured by flow-mediated dilation(FMD)
PAC
plasma aldosterone concentration
PAC
plasma aldosterone concentration
PRA
plasma renin activity
PRA
plasma renin activity
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