The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of Texas Southwestern Medical Center

About this trial

Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. It has been previously shown that this impaired heat dissipation results in burn survivors experiencing higher core temperatures for a given exercise/environmental exposure compared to non-burned individuals. This also holds true with the use of simulated burn injury. When an absorbent material is applied to the skin over a desired amount of body surface area, it replicates a burn injury of the same size (i.e., simulated burn injury). A question that remains unknown is if this impaired thermoregulation in burn survivors would affect post-exercise core temperature recovery, i.e., do burn survivors recover slower than non-burned individuals upon stopping exercise. To that end, the primary objective of this project is to determine the rate at which body temperature and other markers of thermoregulation recover after a bout of exercise in the heat and if this response is different in the same individual with and without simulated burn injury.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

18 and 65 years of age

free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram.

Disqualifiers

Known heart disease

other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, etc. as well as serious abnormalities detected on routine screening.

Individuals who are pregnant, planning to become pregnant, or breastfeeding will be excluded, this will be confirmed in females using a urine pregnancy test.

Taking prescribed medications (such as beta blockers and non-dihydropyridine calcium channel blockers) or over-the-counter medications that have known influences on thermoregulatory response.

Trial design

Design model

Crossover

Treatments tested in this trial

  • Simulated burn injury via application of absorbent and impermeable material over 60% of the body

    Other intervention

    Simulated burn injury via application of absorbent and impermeable material over 60% of the body

Treatment groups

28 Participants
are divided into 4 treatment groups
Group A: Hot and Humid with simulated burnsExperimental treatment 1 intervention
Group B: Hot and Humid without simulated burnsNo intervention 0 interventions
Group C: Hot and Dry with simulated burnsExperimental treatment 1 intervention
Group D: Hot and Dry without simulated burnsNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Core Temperature

Time frame
From baseline to end of 60 minutes of recovery

Secondary outcomes

1

Heart Rate

Time frame
From baseline to the end of 60 minutes of recovery

Other outcomes

Sponsors and contacts

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University of Texas Southwestern Medical Center

Lead sponsor

National Institute of General Medical Sciences (NIGMS)

Collaborator