The Effect of SPecialty cAre on Recovery From Cardiac Arrest Trial (the SPARC Trial)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Pittsburgh
About this trial
This randomized clinical trial will determine if adult participants who are in the emergency department after being resuscitated from a cardiac arrest outside of the hospital benefit from care delivered at specialized centers.
The main question that it will answer is whether transferring participants to a hospital with a specialized cardiac arrest service improves recovery of function after 90 days.
Participants will receive all usual medical care, but some participants will be offered transfer to a regional cardiac arrest center and others will be offered care at the closest appropriate hospital. Investigators will interview participants after 90 days to assess their recovery.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Out-of-hospital cardiac arrest
Resuscitated from cardiac arrest with palpable pulse in the emergency department
Treated at one of participating hospital emergency departments
Age ≥18 years
Disqualifiers
Known prior advanced directives or decision to limit critical care
Known pre-arrest dependent functional status (e.g., living in a skilled nursing facility, hospice or bedbound)
Arrest in the emergency department >4 hours after arrival
Traumatic etiology of arrest
Trial design
Design model
Parallel
Treatments tested in this trial
Transfer to specialty care
Other interventionInterfacility transport and treatment at the specialty care hospital
Usual care
Other interventionHospitalization and treatment at the closest appropriate facility
Treatment groups
1,618 Participants
are divided into 2 treatment groupsGroup A: Transfer to specialty careExperimental treatment 1 intervention
Group B: Usual careActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Modified Rankin Scale
The Modified Rankin Scale (mRS) is a measure of functional recovery, measured 90 days after cardiac arrest. A Modified Rankin Score (mRS) of 0 corresponds to full functional recovery and a Modified Rankin Score (mRS) of 6 corresponds to death, with progressively worse functional outcomes at higher scores. Intermediate values reflect progressive functional dependence, with higher scores reflecting greater dependence on others.
Time frame
90 Days post arrestSecondary outcomes
1
Survival to ICU Admission
Time frame
24 hours post arrest2
72 hour survival
Time frame
72 hours post arrest3
mRS at hospital discharge
Time frame
Up to 6 months post arrestSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Pittsburgh
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Source ClinicalTrials.gov