This study aims to investigate shorter vs. standard filter lifespans in critically ill patients receiving continuous renal replacement therapy (CRRT) for acute kidney injury (AKI). The aim of this trial is to reliably implement,scheduled filter changes and to investigate whether shorter filter lifetime is associated with a lower incidence in rate of new infections.
Adult ≥ 18 years
Critically ill patients with severe AKI consistent with KDIGO stage 3 and an absolute indication for CRRT
Written consent form from the patient or legal representative or authorized representative or emergency inclusion
End-stage kidney disease or chronic dialysis dependence
Chronic kidney disease with eGFR<20ml/min/1.73 m²
Prior kidney transplant
Prior renal replacement therapy during the index admission before randomization
Parallel
time span of filter change
Other interventionThe time span of the filter change during continuous renal replacement therapy will be specified
Mean filter lifespan per patient
Comparison of mean filter lifespans between study groups
Protocol adherence as documented filter change within the specified period
Proportion of protocol adherent patients, defined as patients with mean filter lifespan within the pre-specified time window in each arm (intervention group: 36±3hours; control group: 48-72hours
New intensive care unit (ICU)-associated acquired infection up to day 30
Rate of new ICU-acquired infections, defined as new infection in patients with pre-existing infection but with another pathogen than baseline or without baseline infection. All infections need to be culture proven. Only the first infection per patient will be considered
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