This clinical study aims to compare the clinical and radiographic outcomes of four different scaffolds used in regenerative endodontic treatment of previously root canal-treated permanent teeth requiring retreatment.
Participants will be randomly assigned to one of four groups based on the scaffold used: induced blood clot, injectable platelet-rich fibrin (i-PRF), advanced platelet-rich fibrin (A-PRF), or advanced platelet-rich fibrin plus (A-PRF+). All participants will receive the same root canal disinfection and restorative procedures, with the scaffold type differing between the groups.
Participants will be evaluated clinically and radiographically at 3, 6, and 12 months after treatment. The study will compare the groups in terms of the resolution of clinical signs and symptoms and changes observed on radiographic and cone-beam computed tomography images.
Patients aged 16-40 who are systemically healthy
Patients who have a permanent tooth with a single root canal and fully developed root that requires retreatment
Patients who may or may not have periapical radiolucency
Patients who require antibiotic prophylaxis
Patients with systemic conditions such as diabetes or hematological disorders
Patients who have taken antibiotics, anti-inflammatory medications, and/or antidepressants within the past three weeks
Patients who are pregnant or suspect they may be pregnant during treatment